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Buprenorphine

What the body does with Buprenorphine, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

BuprenorphinetakenNorbuprenorphinemetaboliteExitBile duct and kidney

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. 0 → onsetdose

    Onset

    Within 30 min 1

  2. doseabsorbed

    Bioavailability

    Sublingual: 30%; Intranasal: 48%; Buccal: 65% IV/IM: 100% 1

  3. hoursbreakdown

    Metabolism

    Liver (CYP3A4, CYP2C8) 1

  4. hoursmade from it

    Metabolites

    Norbuprenorphine, Hydroxybuprenorphine, Hydroxynorbuprenorphine, Buprenorphine glucuronide 1

  5. half-lifehalf gone

    Elimination half-life

    37 hours (range 20–70 hours) 1

  6. durationeffects

    Duration of action

    Up to 24 hrs 1

  7. exitleaves the body

    Excretion

    Bile duct and kidney 1

Source

  1. Wikipedia, Buprenorphine, drug infobox (revision 1378619735), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.