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Axitinib

What the body does with Axitinib, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

AxitinibtakenExitFeces (41%; 12% as unchanged drug), urin

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. doseabsorbed

    Bioavailability

    58% 1

  2. hoursbreakdown

    Metabolism

    Liver (mostly CYP3A4/CYP3A5-mediated but with some contributions from CYP1A2, CYP2C19, UGT1A1) 1

  3. half-lifehalf gone

    Elimination half-life

    2.5-6.1 hours 1

  4. exitleaves the body

    Excretion

    Feces (41%; 12% as unchanged drug), urine (23%) 1

Source

  1. Wikipedia, Axitinib, drug infobox (revision 1335549960), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.