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Atomoxetine

What the body does with Atomoxetine, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

AtomoxetinetakenExit2D6 EMs: urine (>96%), feces (1–2%); 2D6

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. 0 → onsetdose

    Onset

    1–2 hours (Tₘₐₓ) 1

  2. doseabsorbed

    Bioavailability

    2D6 EMs: 94%; 2D6 PMs: 63% 1

  3. hoursbreakdown

    Metabolism

    Liver: ring hydroxylation (CYP2D6, others), benzylic hydroxylation, N-demethylation (CYP2C19), glucuronidation (UGTs) 1

  4. hoursmade from it

    Metabolites

    4-Hydroxyatomoxetine; N-Desmethylatomoxetine; N-Desmethyl-4-hydroxyatomoxetine; Glucuronide conjugates 1

  5. half-lifehalf gone

    Elimination half-life

    2D6 EMs: 4.5–5.3 h; 2D6 PMs: 19–22 h 1

  6. exitleaves the body

    Excretion

    2D6 EMs: urine (>96%), feces (1–2%); 2D6 PMs: urine (80%), feces (13–22%) 1

Source

  1. Wikipedia, Atomoxetine, drug infobox (revision 1376872697), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.