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Asenapine

What the body does with Asenapine, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

AsenapinetakenExitKidney (50%), Fecal (40%; ~5–16% as unch

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. doseabsorbed

    Bioavailability

    35% (sublingual), <2% (oral), transdermal bioavailability is significantly higher than sublingual 1

  2. hoursbreakdown

    Metabolism

    hepatic (glucurinodation by UGT1A4 and oxidative metabolism by CYP1A2) 1

  3. half-lifehalf gone

    Elimination half-life

    24 hours (sublingual), 30 hours (transdermal), 33.9 hours (transdermal) 1

  4. exitleaves the body

    Excretion

    Kidney (50%), Fecal (40%; ~5–16% as unchanged drug in feces) 1

Source

  1. Wikipedia, Asenapine, drug infobox (revision 1375768934), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.