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Apalutamide

What the body does with Apalutamide, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

ApalutamidetakenN-DesmethylapalutamidemetaboliteExitUrine: 65%; Feces: 24%

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. doseabsorbed

    Bioavailability

    100% 1

  2. hoursbreakdown

    Metabolism

    Liver (CYP2C8, CYP3A4) 1

  3. hoursmade from it

    Metabolites

    NDMA 1

  4. hoursfrom the article text

    What else it turns into

    “The plasma protein binding of apalutamide is 96%, while that of its major metabolite N-desmethylapalutamide is 95%, both irrespective of concentration.” 2

  5. half-lifehalf gone

    Elimination half-life

    Apalutamide: 3–4 days (at steady-state) 1

  6. exitleaves the body

    Excretion

    Urine: 65%; Feces: 24% 1

Sources

  1. Wikipedia, Apalutamide, drug infobox (revision 1370134765), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.
  2. Wikipedia, Apalutamide, article text (revision 1370134765), CC BY-SA 4.0. Sentences quoted as they appear.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.