intoxicant.wiki2catechol4school
← All metabolic timelinesMetabolic highway

Amoxapine

What the body does with Amoxapine, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

Amoxapinetaken7-HydroxyamoxapinemetaboliteExitRenal (60%), feces (18%)

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. doseabsorbed

    Bioavailability

    >60% 1

  2. hoursbreakdown

    Metabolism

    Hepatic (cytochrome P450 system) 1

  3. hoursfrom the article text

    What else it turns into

    “7-Hydroxyamoxapine, a major active metabolite of amoxapine, is a more potent dopamine receptor antagonist and contributes to its neuroleptic efficacy, whereas 8-Hydroxyamoxapine is a norepinephrine reuptake inhibitor but a stronger serotonin reuptake inhibitor and helps to balance amoxapine's ratio of serotonin to norepinephrine transporter blockade.” 2

  4. half-lifehalf gone

    Elimination half-life

    8–10 hours (30 hours for chief active metabolite) 1

  5. exitleaves the body

    Excretion

    Renal (60%), feces (18%) 1

Sources

  1. Wikipedia, Amoxapine, drug infobox (revision 1373846822), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.
  2. Wikipedia, Amoxapine, article text (revision 1373846822), CC BY-SA 4.0. Sentences quoted as they appear.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.