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Amphetamine

What the body does with Amphetamine, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

Amphetaminetaken4-hydroxyamphetaminemetaboliteN-hydroxyamphetaminemetaboliteExitPrimarily renal; pH-dependent range: 1–7

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. 0 → onsetdose

    Onset

    IR dosing: 30-45 minutes; XR dosing: 1.5–2 hours 1

  2. doseabsorbed

    Bioavailability

    Oral: ~90% 1

  3. hoursbreakdown

    Metabolism

    CYP2D6, DBH, FMO3 1

  4. hoursmade from it

    Metabolites

    4-hydroxyamphetamine, 4-hydroxynorephedrine, 4-hydroxyphenylacetone, N-hydroxyamphetamine, benzoic acid, hippuric acid, norephedrine, phenylacetone 1

  5. half-lifehalf gone

    Elimination half-life

    D-amph: 9–11 hours; L-amph: 11–14 hours; pH-dependent: 7–34 hours 1

  6. durationeffects

    Duration of action

    IR dosing: 3–6 hours; XR dosing: 8–12 hours 1

  7. exitleaves the body

    Excretion

    Primarily renal; pH-dependent range: 1–75% 1

Source

  1. Wikipedia, Amphetamine, drug infobox (revision 1378751525), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.