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5-MeO-DMT

What the body does with 5-MeO-DMT, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

5-MeO-DMTtakenBufoteninmetabolite

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. 0 → onsetdose

    Onset

    Inhalation: seconds or 3–4 min (but up to 10–15 min); Intranasal: 3–15 min; Intramuscular: 1–6 min; Intravenous: ≤1 minute; Oral (with harmaline): 15–18 min 1

  2. doseabsorbed

    Bioavailability

    Oral: inactive (without an MAOI) or weak 1

  3. hoursbreakdown

    Metabolism

    Oxidative deamination (MAO), O-demethylation (CYP2D6) 1

  4. hoursmade from it

    Metabolites

    Bufotenin 1

  5. half-lifehalf gone

    Elimination half-life

    Intranasal: 15–26 min; Sublingual: 28 min 1

  6. durationeffects

    Duration of action

    Inhalation: 5–30 min, but up to 1–2 hours; Intranasal: 45–70 min; Intramuscular: ≤60 min; Intravenous: 10 min; Oral (with harmaline) ≥3–4 hours 1

Source

  1. Wikipedia, 5-MeO-DMT, drug infobox (revision 1377950930), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.