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Substance

Vildagliptin/metformin

Original Wikipedia articleen.wikipedia.org/wiki/Vildagliptin/metformin revision used (24 October 2026)

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Overview

Vildagliptin/metformin, sold under the brand name Eucreas among others, is a fixed-dose combination anti-diabetic medication for the treatment of type 2 diabetes. It was approved for use in the European Union in November 2007, and the approval was updated in 2008. It combines 50 mg vildagliptin with either 500, 850, or 1000 mg metformin.[1–6] WP

The most common side effects include nausea (feeling sick), vomiting, diarrhea, abdominal (tummy) pain and loss of appetite.[2][4][5] WP

Uses, dosage and effects

Medical uses

Vildagliptin/metformin is indicated in the treatment of type-2 diabetes mellitus:[2][4][5] WP

  • it is indicated in the treatment of adults who are unable to achieve sufficient glycaemic control at their maximally tolerated dose of oral metformin alone or who are already treated with the combination of vildagliptin and metformin as separate tablets.[2][4][5] WP
  • it is indicated in combination with a sulphonylurea (i.e. triple combination therapy) as an adjunct to diet and exercise in patients inadequately controlled with metformin and a sulphonylurea.[2][4][5] WP
  • it is indicated in triple combination therapy with insulin as an adjunct to diet and exercise to improve glycaemic control in patients when insulin at a stable dose and metformin alone do not provide adequate glycaemic control.[2][4][5] WP

Chemistry

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Harm reduction information

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Pop culture

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Sources

  1. Journal / agency Halimi S, Schweizer A, Minic B, Foley J, Dejager S. Combination treatment in the management of type 2 diabetes: focus on vildagliptin and metformin as a single tablet. Vascular Health and Risk Management. 2008. doi:10.2147/vhrm.s2503 · PMID 18827867 · PMC2515409
  2. Journal / agency Eucreas EPAR. 23 April 2018
  3. Other EU approves Novartis's Eucreas diabetes drug. February 25, 2008
  4. Journal / agency Icandra EPAR. 12 April 2018
  5. Journal / agency Zomarist EPAR. 21 April 2017
  6. Other Galvumet

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