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Compound

Triflupromazine

Also called Fluopromazine, Trifluopromazine, Vesprin

Original Wikipedia articleen.wikipedia.org/wiki/Triflupromazine revision used (24 October 2026)

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Overview

Triflupromazine (Vesprin) is an antipsychotic medication of the phenothiazine class. Among different effects of triflupromazine indication for use of this drug is severe emesis and severe hiccups. Due to its potential side effects (triflupromazine has higher risk for side effects than many other antipsychotics) it is not gold standard in antiemetic therapy.[1][2] WP

Serious side effects of triflupromazine can be akathisia and tardive dyskinesia as well as the rare, but potentially fatal, neuroleptic malignant syndrome. WP

It has also been reported to target tubulin, blocking its polymerization.[3] WP

Chemistry

Formula
C18H19F3N2S PC
CAS number
146-54-3 PC
Molar mass (g/mol)
352.4 PC
IUPAC name (computed by PubChem)
N,N-dimethyl-3-[2-(trifluoromethyl)phenothiazin-10-yl]propan-1-amine PC
SMILES
CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)C(F)(F)F PC
InChIKey
XSCGXQMFQXDFCW-UHFFFAOYSA-N PC
PubChem CID
5568

Harm reduction information

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Sources

  1. Journal / agency Thiele R. Triflupromazine as a tranquilizer and antiemetic drug in internal medicine. Medizinische Klinik. September 1965. PMID 5862106
  2. Harm reduction site Triflupromazine
  3. Journal / agency Baksheeva VE, La Rocca R, Allegro D, Derviaux C, Pasquier E, Roche P, Morelli X, Devred F, Golovin AV, Tsvetkov PO. NanoDSF Screening for Anti-tubulin Agents Uncovers New Structure–Activity Insights. Journal of Medicinal Chemistry. 2025. doi:10.1021/acs.jmedchem.5c01008 · PMID 40815226 · PMC12406199

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.