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Compound

Tolterodine

Also called Urotrol, Unidet

Original Wikipedia articleen.wikipedia.org/wiki/Tolterodine revision used (24 October 2026)

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Overview

Tolterodine, sold under the brand name Detrol among others, is a medication used to treat frequent urination, urinary incontinence, or urinary urgency. Effects are seen within an hour. It is taken by mouth.[1][2][3] WP

Common side effects include headache, dry mouth, constipation, and dizziness. Serious side effects may include angioedema, urinary retention, and QT prolongation. Use in pregnancy and breastfeeding are of unclear safety. It works by blocking muscarinic receptors in the bladder thus decreasing bladder contractions.[1][2][4] WP

Tolterodine was approved for medical use in 1998. It is available as a generic medication. In 2020, it was the 271st most commonly prescribed medication in the United States, with more than 1 million prescriptions.[1][2][5][6] WP

Uses, dosage and effects

Medical uses

Detrusor overactivity (DO, contraction of the muscular bladder wall) is the most common form of urinary incontinence (UI) in older adults. It is characterized by uninhibited bladder contractions causing an uncontrollable urge to void. Urinary frequency, urge incontinence and nocturnal incontinence occur. Abnormal bladder contractions that coincide with the urge to void can be measured by urodynamic studies. Treatment is bladder retraining, pelvic floor therapy or with drugs that inhibit bladder contractions such as oxybutynin and tolterodine.[7] WP⚠ Wikipedia itself has flagged this text: medical citation needed.⚠ Wikipedia itself has flagged this text: unreliable medical source?.

Risks and side effects

Side effects

Known side effects: WP

The following reactions have been reported in people who have taken tolterodine since it has become available: WP

  • Allergic reactions including swelling[8] WP
  • Rapid heartbeat or abnormal heartbeat[8] WP
  • Accumulation of fluid in the arms and legs[8] WP

Tolterodine is not recommended for use in people with myasthenia gravis and angle closure glaucoma. WP

Pharmacology

Pharmacology

Tolterodine acts on M₂ and M₃ subtypes of muscarinic receptors whereas older antimuscarinic treatments for overactive bladder act more specifically on M₃ receptors. WP⚠ Wikipedia itself has flagged this text: medical citation needed.

Tolterodine, although it acts on all types of receptors, has fewer side effects than oxybutynin (M₃ and M₁ selective, but more so in the parotid than in the bladder) as tolterodine targets the bladder more than other areas of the body. WP⚠ Wikipedia itself has flagged this text: medical citation needed.

Legal status

Brand names

It is marketed by Pfizer in Canada and the United States under the brand name Detrol, while in Indonesia it is marketed under the brand name Detrusitol. In Egypt it is also found under the trade names Tolterodine by Sabaa and Incont L.A. by Adwia. WP

In the US, Detrol is marketed by Viatris after Upjohn was spun off from Pfizer.[9][10][11] WP

Chemistry

Formula
C22H31NO PC
CAS number
124937-51-5 PC
Molar mass (g/mol)
325.5 PC
IUPAC name (computed by PubChem)
2-[(1R)-3-[di(propan-2-yl)amino]-1-phenylpropyl]-4-methylphenol PC
SMILES
CC1=CC(=C(C=C1)O)[C@H](CCN(C(C)C)C(C)C)C2=CC=CC=C2 PC
InChIKey
OOGJQPCLVADCPB-HXUWFJFHSA-N PC
PubChem CID
443879

Harm reduction information

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Sources

  1. Other British national formulary: BNF 76. 2018
  2. Other Tolterodine Tartrate Monograph for Professionals
  3. Journal / agency Narain S, Parmar M. StatPearls [Internet]. January 2021. PMID 32491781
  4. Other Tolterodine Pregnancy and Breastfeeding Warnings
  5. Other The Top 300 of 2020
  6. Other Tolterodine - Drug Usage Statistics
  7. Other Bladder retraining
  8. Other Tolterodine (oral route) - Side effects & dosage
  9. Other Pfizer Completes Transaction to Combine Its Upjohn Business with Mylan. 16 November 2020
  10. Other Detrol
  11. Other Brands. 16 November 2020

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.