Tolibut
Dosage
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Mixing
For best safety practice, don't mix this drug with other depressants.
Why: respiratory depression. PsychonautWiki says:
- “Respiratory depression (also known as hypoventilation) can be described as a reduced urge to breathe that can be fatal depending on its intensity.” (PsychonautWiki, Respiratory depression, revision 150612)
- “... otherwise safe dosages of these compounds can become fatal when combined with even small amounts of other classes of depressant. For example, benzodiazepines combined with opioids are an extremely common cause of fatal respiratory depression. It is therefore strongly discouraged to combine these depressants at any dosage range.” (PsychonautWiki, Respiratory depression, revision 150612)
- “The most common cause of substance-related deaths is the combination of depressants (such as opiates, benzodiazepines, or alcohol) with other depressants.” (PsychonautWiki, Responsible drug use, revision 168206)
- “This combination potentiates the muscle relaxation, amnesia, sedation, and respiratory depression caused by one another. At higher doses, it can lead to a sudden, unexpected loss of consciousness along with a dangerous amount of depressed respiration.” (PsychonautWiki, dangerous interactions table, "Depressants" row, revision 156847)
Quotes from PsychonautWiki, CC BY-SA 4.0.
Acute combinations: what happens when these are taken close together. Entries backed by a medical journal or agency are listed first.
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Risks and toxicity
Testing
Effects
Overview
Analogue of GABA, and the 4-methyl analogue of Phenibut. Has similar effects, acts on GABA(B). TS
Tolibut, also known as 3-(p-tolyl)-4-aminobutyric acid (or β-(4-methylphenyl)-GABA), is drug that was developed in Russia. It is an analogue of γ-aminobutyric acid (GABA) and is the 4-methyl analogue of phenibut, and is also an analogue of baclofen where the 4-chloro substitution has been replaced with a 4-methyl substitution. Tolibut has been described as possessing analgesic, tranquilizing, and neuroprotective properties. It is not fully clear as to whether the drug was ever approved or used medically in Russia.[1–4] WP
History
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References
- Journal / agency Tyurenkov IN, Borodkina LE, Bagmetova VV. Functional aspects of neuroprotective effects of new salts and compositions of baclofen in the convulsive syndrome caused by electroshock. Bulletin of Experimental Biology and Medicine. September 2012. doi:10.1007/s10517-012-1806-5 · PMID 23113265
- Journal / agency Morozov IS, Kovalev GI, Maisov NI, Kovalev GV, Raevskii KS. Effect of analogs of γ -aminobutyric acid on the uptake of [3H]-γ -aminobutyric acid by synaptosomes of the rat brain. Pharmaceutical Chemistry Journal. January 1977. doi:10.1007/BF00779108
- Journal / agency Dmitriev AV, Andreev NI. The spectrum of analgesic activity of baclofen and tolibut. Farmakologiia I Toksikologiia. 1987. PMID 3556547
- Journal / agency Artem'ev II, Darinskiĭ I, Sologub MI. A hypothesis of the possible mechanism of the action of analgesic agents at the neuronal level. Eksperimental'naia i Klinicheskaia Farmakologiia. 1992. PMID 1363942
Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), TripSit factsheets, PubChem (public domain). Each value links to the exact revision it came from.