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Compound

Thozalinone

Also called Tozalinonum, Stimsen

Original Wikipedia articleen.wikipedia.org/wiki/Thozalinone revision used (24 October 2026)

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Overview

Thozalinone (USAN) (brand name Stimsen; former developmental code name CL-39808) is a psychostimulant that has been used as an antidepressant in Europe. It has also been trialed as an anorectic. Thozalinone is described as a "dopaminergic stimulant", and likely acts via inducing the release of dopamine and to a minimal extent norepinephrine; similar to analogue pemoline, it is reportedly devoid of abuse potential unlike most other dopaminergic psychostimulants.[1–8] WP

Chemistry

Formula
C11H12N2O2 PC
CAS number
655-05-0 PC
Molar mass (g/mol)
204.22 PC
IUPAC name (computed by PubChem)
2-(dimethylamino)-5-phenyl-1,3-oxazol-4-one PC
SMILES
CN(C)C1=NC(=O)C(O1)C2=CC=CC=C2 PC
InChIKey
JJSHYECKYLDYAR-UHFFFAOYSA-N PC
PubChem CID
12602
IUPAC name
(RS)-2-(Dimethylamino)-5-phenyl-1,3-oxazol-4(5H)-one WP

Harm reduction information

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Sources

  1. Other Elks J. The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014
  2. Journal / agency Greenblatt EN, Osterberg AC. Some pharmacologic properties of thozalinone, a new excitant. Toxicology and Applied Pharmacology. July 1965. doi:10.1016/0041-008X(65)90042-6 · PMID 4378772
  3. Other Dictionary of organic compounds. 1996
  4. Other Merck index on CD-ROM: Windows. 1998
  5. Journal / agency Gallant DM, Bishop MP, Scrignar CB, Hornsby L, Moore B, Inturrisi BB. A double-blind study of thozalinone (C1 39,808) in depressed outpatients. Current Therapeutic Research, Clinical and Experimental. December 1966. PMID 4962734
  6. Journal / agency Leite AC, Liepen LL, Costa VP. Clinical trial of Stimsem Thozalinone in the treatment of obese patients. Revista Brasileira de Medicina. September 1971. PMID 5139648
  7. Journal / agency Yen-Koo HC, Balazs T. Detection of dopaminergic supersensitivity induced by neuroleptic drugs in mice. Drug and Chemical Toxicology. 1980. doi:10.3109/01480548009108286 · PMID 6112126
  8. Journal / agency Yen-Koo HC, Davis DA, Balazs T. Inhibition of dopaminergic agonist-induced gnawing behavior by neuroleptic drugs in mice. Drug and Chemical Toxicology. 1985. doi:10.3109/01480548509041072 · PMID 2868876

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.