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Compound

Telmisartan/hydrochlorothiazide

Also called MicardisPlus, Telsar-H, Telma-H

Original Wikipedia articleen.wikipedia.org/wiki/Telmisartan/hydrochlorothiazide revision used (24 October 2026)

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Overview

Telmisartan/hydrochlorothiazide, sold under the brand name Micardis HCT among others, is a fixed-dose combination medication used to treat high blood pressure. It is a combination of telmisartan an angiotensin II receptor antagonist with hydrochlorothiazide a diuretic. It may be used if telmisartan by itself is not sufficient. It is taken by mouth.[1][2] WP

Common side effects include dizziness, upper respiratory tract infections, nausea, diarrhea, and tiredness. Severe side effects may include kidney problems, electrolyte problems, and allergic reactions. Use during pregnancy may harm the baby. Telmisartan works by blocking the effects of angiotensin II while hydrochlorothiazide works by decreasing the kidneys' ability to retain water.[1] WP

The combination was approved for medical use in the United States in November 2000, and in the European Union in April 2002. The combination is on the World Health Organization's List of Essential Medicines. It is available as a generic medication.[2–7] WP

Chemistry

Formula
C40H38ClN7O6S2 PC
CAS number
485391-74-0 PC
Molar mass (g/mol)
812.4 PC
IUPAC name (computed by PubChem)
6-chloro-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide;2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl]methyl]phenyl]benzoic acid PC
SMILES
CCCC1=NC2=C(N1CC3=CC=C(C=C3)C4=CC=CC=C4C(=O)O)C=C(C=C2C)C5=NC6=CC=CC=C6N5C.C1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl PC
InChIKey
OZCVMXDGSSXWFT-UHFFFAOYSA-N PC
PubChem CID
216293

Harm reduction information

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Sources

  1. Journal / agency Micardis HCT- telmisartan and hydrochlorothiazide tablet. 27 August 2020
  2. Other British national formulary: BNF 76. 2018
  3. Journal / agency Drug Approval Package: Micardis HCT (telmisartan/hydrochlorothiazide) NDA #021162. 11 March 2004
  4. Other Hydrochlorothiazide and telmisartan Uses, Side Effects & Warnings
  5. Journal / agency MicardisPlus EPAR. 17 September 2018
  6. Journal / agency PritorPlus EPAR. 17 September 2018
  7. Other World Health Organization. World Health Organization model list of essential medicines: 21st list 2019. 2019

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.