Tazobactam
Also called Tazobactam acid
Overview
Tazobactam is a pharmaceutical drug that inhibits the action of bacterial β-lactamases, especially those belonging to the SHV-1 and TEM groups. It is commonly used as its sodium salt, tazobactam sodium. WP
Tazobactam is combined with the extended spectrum β-lactam antibiotic piperacillin in the drug piperacillin/tazobactam, used in infections due to Pseudomonas aeruginosa. Tazobactam broadens the spectrum of piperacillin by making it effective against organisms that express β-lactamase and would normally degrade piperacillin.[1] WP
Tazobactam was patented in 1982 and came into medical use in 1992.[2] WP
Chemistry
- Formula
- C10H12N4O5S PC
- CAS number
- 89786-04-9 PC
- Molar mass (g/mol)
- 300.29 PC
- IUPAC name (computed by PubChem)
- (2S,
3S, PC5R) - 3- methyl- 4, 4, 7- trioxo- 3- (triazol- 1- ylmethyl) - 4lambda6- thia- 1- azabicyclo[3.2.0] heptane- 2- carboxylic acid - SMILES
- C[C@@]
1([C@@H] PC(N2[C@H] (S1(=O) =O) CC2=O) C(=O) O) CN3C=CN=N3 - InChIKey
- LPQZKKCYTLCDGQ-
WEDXCCLWSA- PCN - PubChem CID
- 123630
- IUPAC name
- (2S,
3S, WP5R) - 3- Methyl- 7- oxo- 3- (1H- 1, 2, 3- triazol- 1- ylmethyl) - 4- thia- 1- azabicyclo
Harm reduction information
No harm reduction data is on file for this compound yet. That means no dose, timing or combination data from PsychonautWiki or TripSit. Please don't guess a dose from similar compounds. If you have taken it and feel unwell, contact emergency services or a poison control center.
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Sources
- Journal / agency Yang Y, Rasmussen BA, Shlaes DM. Class A beta-lactamases--enzyme-inhibitor interactions and resistance. Pharmacology & Therapeutics. August 1999. doi:10.1016/S0163-7258(99)00027-3 · PMID 10511459
- Other Fischer J, Ganellin CR. Analogue-based Drug Discovery. 2006
Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.