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Compound

Talbutal

Also called Lotusate, Profundol, sec-Butyl allyl barbituric acid

Original Wikipedia articleen.wikipedia.org/wiki/Talbutal revision used (24 October 2026)

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Overview

Talbutal (Lotusate) is a barbiturate with a short to intermediate duration of action. It is a structural isomer of butalbital. Talbutal is a schedule III drug in the U.S. WP

Risks and side effects

Toxicity

Symptoms of acute barbiturate poisoning include drowsiness, confusion, coma, respiratory depression, hypotension, and shock.[1] WP

Pharmacology

Pharmacology

Talbutal is a short to intermediate-acting barbiturate. Barbiturates act as nonselective depressants of the central nervous system (CNS), capable of producing all levels of CNS mood alteration from excitation to mild sedation, hypnosis, and deep coma. In sufficiently high therapeutic doses, barbiturates induce anesthesia.[1] WP

Mechanism of action

Talbutal binds at a distinct binding site associated with a Cl⁻ ionophore at the GABAA receptor, increasing the duration of time for which the Cl⁻ ionophore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. WP

Chemistry

Formula
C11H16N2O3 PC
CAS number
115-44-6 PC
Molar mass (g/mol)
224.26 PC
IUPAC name (computed by PubChem)
5-butan-2-yl-5-prop-2-enyl-1,3-diazinane-2,4,6-trione PC
SMILES
CCC(C)C1(C(=O)NC(=O)NC1=O)CC=C PC
InChIKey
BJVVMKUXKQHWJK-UHFFFAOYSA-N PC
PubChem CID
8275
IUPAC name
(RS)-5-allyl-5-sec-butylpyrimidine-2,4,6(1H,3H,5H)-trione WP

Harm reduction information

No harm reduction data is on file for this compound yet. That means no dose, timing or combination data from PsychonautWiki or TripSit. Please don't guess a dose from similar compounds. If you have taken it and feel unwell, contact emergency services or a poison control center.

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Pop culture

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Sources

  1. Other Mutschler E, Schäfer-Korting M. Arzneimittelwirkungen. 2001

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.