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Compound

Sultopride

Also called Barnetil, Topral, Sultroprida

Original Wikipedia articleen.wikipedia.org/wiki/Sultopride revision used (24 October 2026)

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Overview

Sultopride (trade names Barnetil, Barnotil, Topral) is an atypical antipsychotic of the benzamide chemical class used in Europe, Japan, and Hong Kong for the treatment of schizophrenia. It was launched by Sanofi-Aventis in 1976. Sultopride acts as a selective D₂ and D₃ receptor antagonist. It has also been shown to have clinically relevant affinity for the GHB receptor as well, a property it shares in common with amisulpride and sulpiride.[1–5] WP

Chemistry

Formula
C17H26N2O4S PC
CAS number
53583-79-2 PC
Molar mass (g/mol)
354.5 PC
IUPAC name (computed by PubChem)
N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxybenzamide PC
SMILES
CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)CC)OC PC
InChIKey
UNRHXEPDKXPRTM-UHFFFAOYSA-N PC
PubChem CID
5357

Harm reduction information

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Pop culture

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Sources

  1. Other Miguel Vela J, Buschmann H, Holenz J, Párraga A, Torrens A. Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. 2007
  2. Other Swiss Pharmaceutical Society. Index Nominum 2000: International Drug Directory (Book with CD-ROM). 2000
  3. Other European Drug Index. 1998
  4. Journal / agency Burstein ES, Ma J, Wong S, Gao Y, Pham E, Knapp AE, Nash NR, Olsson R, Davis RE, Hacksell U, Weiner DM, Brann MR. Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist. The Journal of Pharmacology and Experimental Therapeutics. December 2005. doi:10.1124/jpet.105.092155 · PMID 16135699
  5. Journal / agency Maitre M, Ratomponirina C, Gobaille S, Hodé Y, Hechler V. Displacement of [3H] gamma-hydroxybutyrate binding by benzamide neuroleptics and prochlorperazine but not by other antipsychotics. European Journal of Pharmacology. April 1994. doi:10.1016/0014-2999(94)90248-8 · PMID 7914168

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.