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Compound

Sulfadimidine

Also called Sulfamethazine, Sulfadimerazine, Sulphamethazine

Original Wikipedia articleen.wikipedia.org/wiki/Sulfadimidine revision used (24 October 2026)

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Overview

Sulfadimidine or sulfamethazine is a sulfonamide antibacterial. WP

There are non-standardized abbreviations for it as "sulfadimidine" (abbreviated SDI and more commonly but less reliably SDD) and as "sulfamethazine" (abbreviated SMT and more commonly but less reliably SMZ). Other names include sulfadimerazine, sulfadimezine, and sulphadimethylpyrimidine.[1–8] WP⚠ Part of this sentence could not be copied from the source. Open the source to read it in full.⚠ Wikipedia itself has flagged this text: citation needed.

Toxicity

Median lethal dose (LD50) in animals

Quoted from PubChem's Non-Human Toxicity Values, which come from the Hazardous Substances Data Bank (HSDB). PubChem describes them as: “Quantitative non-human toxicity values (e.g., lethal dose) for this compound. The data shown here are mostly for lab animals (e.g., rat, mouse, guinea pig, and rabbit).” and defines the “LD50 (median lethal dose, the estimated amount of a chemical expected to kill 50% of test animals in a single dose)”. PC

LD50 (as the source gives it)Reference
LD50 Mouse ip 1.06 g/kg PCO'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge, UK: Royal Society of Chemistry, 2013., p. 1649 (via HSDB record 4157)

Chemistry

Formula
C12H14N4O2S PC
CAS number
57-68-1 PC
Molar mass (g/mol)
278.33 PC
IUPAC name (computed by PubChem)
4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide PC
SMILES
CC1=CC(=NC(=N1)NS(=O)(=O)C2=CC=C(C=C2)N)C PC
InChIKey
ASWVTGNCAZCNNR-UHFFFAOYSA-N PC
PubChem CID
5327
IUPAC name
4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzene-1-sulfonamide WP

Harm reduction information

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Sources

  1. Journal / agency Romváry A, Simon F. Sulfonamide residues in eggs. Acta Veterinaria Hungarica. 1992. PMID 1476095
  2. Journal / agency Reddy KS, Jain SK, Uppal RP. Pharmacokinetic studies of sulphonamides in poultry. Indian Journal of Animal Sciences. 1988
  3. Journal / agency Kamakura K, Hasegawa M, Koiguchi S, Miyata M, Okamoto K, Narita M, Hirahara Y, Yamana T, Tonogai Y, Ito Y. Studies on the identification of sulfadimidine in pork by high performance liquid chromatography with photodiode array detector and gas chromatograph-mass spectrometry. Eisei Shikenjo Hokoku. Bulletin of National Institute of Hygienic Sciences. 1993. PMID 7920569
  4. Journal / agency Garg SK, Ghosh SS, Mathur VS. Comparative pharmacokinetic study of four different sulfonamides in combination with trimethoprim in human volunteers. International Journal of Clinical Pharmacology, Therapy, and Toxicology. January 1986. PMID 3485584
  5. Journal / agency Peña MS, Salinas F, Mahedero MC, Aaron JJ. Solvent effect on the determination of sulfamethazine by room-temperature photochemically induced fluorescence. Talanta. February 1994. doi:10.1016/0039-9140(94)80113-4 · PMID 18965913
  6. Journal / agency Kaniou S, Pitarakis K, Barlagianni I, Poulios I. Photocatalytic oxidation of sulfamethazine. Chemosphere. July 2005. doi:10.1016/j.chemosphere.2004.11.069 · PMID 15924956
  7. Journal / agency Calvo R, Sarabia S, Carlos R, Du Souich P. Sulfamethazine absorption and disposition: effect of surgical procedures for gastroduodenal ulcers. Biopharmaceutics & Drug Disposition. Mar 1987. doi:10.1002/bdd.2510080203 · PMID 3593892
  8. Journal / agency De Liguoro M, Fioretto B, Poltronieri C, Gallina G. The toxicity of sulfamethazine to Daphnia magna and its additivity to other veterinary sulfonamides and trimethoprim. Chemosphere. June 2009. doi:10.1016/j.chemosphere.2009.02.002 · PMID 19269673

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.