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Substance

Solithromycin

Also called Solithera, Solitromicina

Original Wikipedia articleen.wikipedia.org/wiki/Solithromycin revision used (24 October 2026)

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Overview

Solithromycin (trade name Solithera) is a ketolide antibiotic undergoing clinical development for the treatment of community-acquired pneumonia and other infections.[1][2] WP

Solithromycin exhibits excellent in vitro activity against a broad spectrum of Gram-positive respiratory tract pathogens, including macrolide-resistant strains. Solithromycin has activity against most common respiratory Gram-positive and fastidious Gram-negative pathogens, and is being evaluated for its utility in treating gonorrhea.[3–7] WP

Risks and side effects

Side effects

During a clinical study some patients presented with elevated liver enzyme which may or may not be indicative of hepatotoxicity. This prompted the FDA Antimicrobial Drugs Advisory Committee to vote that the risk to the liver has not been adequately characterized and that further studies need to be conducted. To this extent, the FDA requests a 9,000 patient safety trial as well as restricting the drug. WP

Pharmacology

Mechanism of action

Solithromycin inhibits bacterial translation by binding to the 23S ribosomal RNA, preventing the offending bacteria from synthesizing proteins.[8] WP

Chemistry

Awaiting sourceFormula, structure and identifiers from PubChem.

Harm reduction information

No harm reduction data is on file for this compound yet. That means no dose, timing or combination data from PsychonautWiki or TripSit. Please don't guess a dose from similar compounds. If you have taken it and feel unwell, contact emergency services or a poison control center.

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User reports

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Pop culture

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Sources

  1. Journal / agency Reinert RR. Clinical efficacy of ketolides in the treatment of respiratory tract infections. The Journal of Antimicrobial Chemotherapy. June 2004. doi:10.1093/jac/dkh169 · PMID 15117934
  2. Other Solithromycin
  3. Journal / agency Woosley LN, Castanheira M, Jones RN. CEM-101 activity against Gram-positive organisms. Antimicrobial Agents and Chemotherapy. May 2010. doi:10.1128/AAC.01662-09 · PMID 20176910 · PMC2863667
  4. Journal / agency Farrell DJ, Sader HS, Castanheira M, Biedenbach DJ, Rhomberg PR, Jones RN. Antimicrobial characterisation of CEM-101 activity against respiratory tract pathogens, including multidrug-resistant pneumococcal serogroup 19A isolates. International Journal of Antimicrobial Agents. June 2010. doi:10.1016/j.ijantimicag.2010.01.026 · PMID 20211548
  5. Journal / agency McGhee P, Clark C, Kosowska-Shick KM, Nagai K, Dewasse B, Beachel L, Appelbaum PC. In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. Antimicrobial Agents and Chemotherapy. January 2010. doi:10.1128/AAC.01123-09 · PMID 19884376 · PMC2798494
  6. Journal / agency Putnam SD, Castanheira M, Moet GJ, Farrell DJ, Jones RN. CEM-101, a novel fluoroketolide: antimicrobial activity against a diverse collection of Gram-positive and Gram-negative bacteria. Diagnostic Microbiology and Infectious Disease. April 2010. doi:10.1016/j.diagmicrobio.2009.10.013 · PMID 20022192
  7. Journal / agency Putnam SD, Sader HS, Farrell DJ, Biedenbach DJ, Castanheira M. Antimicrobial characterisation of solithromycin (CEM-101), a novel fluoroketolide: activity against staphylococci and enterococci. International Journal of Antimicrobial Agents. January 2011. doi:10.1016/j.ijantimicag.2010.08.021 · PMID 21075602
  8. Journal / agency Owens B. Solithromycin rejection chills antibiotic sector. Nature Biotechnology. March 2017. doi:10.1038/nbt0317-187 · PMID 28267725

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