Dopamine D1 receptor agonist · Stimulant

SKF-38,393

Also called 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine

Original Wikipedia articleen.wikipedia.org/wiki/SKF-38,393 revision used (24 October 2026)

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Overview

SKF-38393 is a synthetic compound of the 3-benzazepine family which acts as a selective dopamine D₁ and D₅ receptor partial agonist. It has stimulant and anorectic effects.[1][2][3] WP

The trimethylation of SKF-38,393 leads to a named agent called trepipam. As with fenoldopam, the inclusion of a chlorine halogen gave an agent that is called SKF-81,297. WP

Drug class

Dopamine D1 receptor agonist Stimulant WP

From the Wikipedia article's infobox.

Chemistry

Formula: C16H17NO2 PC
CAS number: 67287-49-4 PC
Molar mass (g/mol): 255.31 PC
IUPAC name (computed by PubChem): 5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol PC
SMILES: C1CNCC(C2=CC(=C(C=C21)O)O)C3=CC=CC=C3 PC
InChIKey: JUDKOGFHZYMDMF-UHFFFAOYSA-N PC
PubChem CID: 1242
IUPAC name: 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol WP

Mixing

For best safety practice, don't mix this drug with other stimulants.

Why: vasoconstriction, heart rate and blood pressure. PsychonautWiki says:

“... may be dangerous to combine with other stimulants ... as they can increase one's heart rate and blood pressure to dangerous levels.” (PsychonautWiki, dangerous interactions table, "Stimulants" row, revision 148925)
“Vasoconstriction can be described as a narrowing of the veins and blood vessels which results from a contraction of their muscular wall.” (PsychonautWiki, Vasoconstriction, revision 170337)
“... it can also occur under the influence of traditional stimulants such as methamphetamine, caffeine, and MDMA.” (PsychonautWiki, Vasoconstriction, revision 170337)
“Increased blood pressure is most commonly induced under the influence of heavy dosages of vasoconstricting compounds, such as traditional stimulants and stimulating psychedelics.” (PsychonautWiki, Increased blood pressure, revision 152273)

Quotes from PsychonautWiki, CC BY-SA 4.0.

Harm reduction information

No harm reduction data is on file for this compound yet. That means no dose, timing or combination data from PsychonautWiki or TripSit. Please don't guess a dose from similar compounds. If you have taken it and feel unwell, contact emergency services or a poison control center.

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User reports

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Listings

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Listings

Awaiting sourceTrip report threads and this substance's discussion forum.

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Pop culture

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Sources

Journal / agency Dubois A, Savasta M, Curet O, Scatton B. Autoradiographic distribution of the D1 agonist [3H]SKF 38393, in the rat brain and spinal cord. Comparison with the distribution of D2 dopamine receptors. Neuroscience. September 1986. doi:10.1016/0306-4522(86)90010-2 · PMID 2946980
Journal / agency Trampus M, Ferri N, Adami M, Ongini E. The dopamine D1 receptor agonists, A68930 and SKF 38393, induce arousal and suppress REM sleep in the rat. European Journal of Pharmacology. April 1993. doi:10.1016/0014-2999(93)90823-Z · PMID 8100197
Journal / agency Cooper SJ, Francis J, Rusk IN. The anorectic effect of SK&F 38393, a selective dopamine D1 receptor agonist: a microstructural analysis of feeding and related behaviour. Psychopharmacology. 1990. doi:10.1007/BF02244403 · PMID 1968277

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.