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Substance

Sitagliptin/simvastatin

Original Wikipedia articleen.wikipedia.org/wiki/Sitagliptin/simvastatin revision used (24 October 2026)

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Overview

Sitagliptin/simvastatin, sold under the brand name Juvisync, is a fixed-dose combination anti-diabetic medication used to treat type 2 diabetes and hypercholesterolemia. It contains sitagliptin and simvastatin. Sitagliptin is a dipeptidyl peptidase-4 inhibitor and simvastatin is an HMG-CoA reductase inhibitor. These two disorders commonly occur in people at the same time, and have been typically treated with administration of these medications separately. The combination was approved in 2011, and sold under the brand name Juvisync by Merck. Juvisync was later removed from the market in 2013, due to business reasons.[1][2] WP

Interactions

Drug interactions

Juvisync should not be used with: strong CYP3A4 inhibitors, cyclosporine, danazol, gemfibrozil, and other fibrates. Caution should be used and the patient should be monitored if they are taking the following: amiodarone, dronedarone, ranolazine, calcium channel blockers, niacin, digoxin, coumarin anticoagulants, and colchicine.[3] WP

History

History

In 1991, Merck & Co's simvastatin was approved as an HMG-COA inhibitor to lower the levels of LDL cholesterol. In 2006, Merck & Co's sitagliptin was approved by the FDA for treatment of diabetes mellitus type 2.[4] WP⚠ Wikipedia itself has flagged this text: citation needed.

Legal status

Regulation

Juvisync was the first product to combine a cholesterol lowering drug with a type 2 diabetes drug in the same tablet.[5] WP

Chemistry

Awaiting sourceFormula, structure and identifiers from PubChem.

Harm reduction information

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Sources

  1. Other FDA Approves Juvisync, Combination of Sitagliptin and Simvastatin. October 7, 2011
  2. Journal / agency U.S. Food and Drug Administration. Drugs to be Discontinued
  3. Other RxList: The Internet drug Index. Juvisync Indications & Dosage
  4. Journal / agency Alvey L. FDA Approves New Treatment for Diabetes: First in a New Class of Diabetes Drugs. 2006-10-17
  5. Journal / agency Liscinsky, Morgan. FDA Approves Combination Therapy Juvisync. 2011-10-07

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