intoxicant.wiki2catechol4school
Compound

RU-24213

Also called 2-(3-hydroxy-phenyl)-N-N-propyl-N-phenylethyl-ethylamine

Original Wikipedia articleen.wikipedia.org/wiki/RU-24213 revision used (24 October 2026)

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Overview

RU-24213, also known as 3-hydroxy-N-propyl-N-(phenylethyl)phenethylamine, is a dopamine receptor agonist of the phenethylamine family related to dopamine. It is a selective dopamine D₂-like receptor agonist. Subsequently, however, RU-24213 was found to also act as a potent κ-opioid receptor (KOR) antagonist. It led to the development of the diphenylethylamine series of KOR ligands. RU-24213 was first described in the scientific literature in 1978.[1–6] WP

Chemistry

Formula
C19H25NO PC
Molar mass (g/mol)
283.4 PC
IUPAC name (computed by PubChem)
3-[2-[2-phenylethyl(propyl)amino]ethyl]phenol PC
SMILES
CCCN(CCC1=CC=CC=C1)CCC2=CC(=CC=C2)O PC
InChIKey
QUZUPTMNMJTYGL-UHFFFAOYSA-N PC
PubChem CID
114876

Harm reduction information

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Sources

  1. Journal / agency Daly SA, Waddington JL. New classes of selective D-1 dopamine receptor antagonist provide further evidence for two directions of D-1:D-2 interaction. Neurochemistry International. March 1992. doi:10.1016/0197-0186(92)90226-h · PMID 1365412
  2. Journal / agency Fortin M, Degryse M, Petit F, Hunt PF. The dopamine D2 agonists RU 24213 and RU 24926 are also kappa-opioid receptor antagonists. Neuropharmacology. April 1991. doi:10.1016/0028-3908(91)90068-m · PMID 1677169
  3. Journal / agency Stoof JC, Kebabian JW. Two dopamine receptors: biochemistry, physiology and pharmacology. Life Sciences. December 1984. doi:10.1016/0024-3205(84)90519-8 · PMID 6390056
  4. Journal / agency Spetea M, Schmidhammer H. Handbook of Experimental Pharmacology. 2022. doi:10.1007/164_2020_431 · PMID 33454858
  5. Journal / agency Spetea M, Berzetei-Gurske IP, Guerrieri E, Schmidhammer H. Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist. Journal of Medicinal Chemistry. November 2012. doi:10.1021/jm301258w · PMID 23134120
  6. Journal / agency Nedelec L, Dumont C, Oberlander C, Frechet D, Laurent J. Synthèse et étude de l'activité dopaminergique de dérivés de la di (phénéthyl) amine. European Journal of Medicinal Chemistry. 1978

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.