intoxicant.wiki2catechol4school
Compound

RO4491533

Original Wikipedia articleen.wikipedia.org/wiki/RO4491533 revision used (24 October 2026)

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Overview

RO-4491533 is a drug developed by Hoffmann-La Roche which acts as a potent and selective negative allosteric modulator for group II of the metabotropic glutamate receptors (mGluR2/3), being equipotent at mGluR₂ and mGluR₃ but without activity at other mGluR subtypes. In animal studies, RO-4491533 produced antidepressant effects and reversed the effects of the mGluR2/3 agonist LY-379,268 with similar efficacy but slightly lower potency than the mGluR2/3 antagonist LY-341,495. A number of related compounds are known, with similar effects in vitro and a fairly well characterized structure-activity relationship.[1][2] WP

Chemistry

Formula
C24H20F3N3O PC
CAS number
579482-31-8 PC
Molar mass (g/mol)
423.4 PC
IUPAC name (computed by PubChem)
4-[3-(2,6-dimethyl-4-pyridinyl)phenyl]-7-methyl-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one PC
SMILES
CC1=CC2=C(C=C1C(F)(F)F)NC(=O)CC(=N2)C3=CC=CC(=C3)C4=CC(=NC(=C4)C)C PC
InChIKey
LYTVXCQQTLUEQR-UHFFFAOYSA-N PC
PubChem CID
11158623

Harm reduction information

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Sources

  1. Journal / agency Campo B, Kalinichev M, Lambeng N, El Yacoubi M, Royer-Urios I, Schneider M, Legrand C, Parron D, Girard F, Bessif A, Poli S, Vaugeois JM, Le Poul E, Celanire S. Characterization of an mGluR2/3 negative allosteric modulator in rodent models of depression. Journal of Neurogenetics. December 2011. doi:10.3109/01677063.2011.627485 · PMID 22091727
  2. Journal / agency Hemstapat K, Da Costa H, Nong Y, Brady AE, Luo Q, Niswender CM, Tamagnan GD, Conn PJ. A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors. The Journal of Pharmacology and Experimental Therapeutics. July 2007. doi:10.1124/jpet.106.117093 · PMID 17416742

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