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Dopamine reuptake inhibitor · Pro-motivational agent

PRX-14040

Original Wikipedia articleen.wikipedia.org/wiki/PRX-14040 revision used (24 October 2026)

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Overview

PRX-14040 is a selective dopamine reuptake inhibitor that was developed by Prexa Pharmaceuticals. It has 28-fold selectivity for the dopamine transporter over the norepinephrine transporter. Similarly to various other dopamine reuptake inhibitors, the drug has been found to reverse motivational deficits induced by the dopamine depleting agent tetrabenazine in animals.[1][2][3] WP

Drug class

Dopamine reuptake inhibitor Pro-motivational agent WP

From the Wikipedia article's infobox.

Chemistry

Formula
C17H22Cl3NO2 PC
CAS number
1664382-90-4 PC
Molar mass (g/mol)
378.7 PC
IUPAC name (computed by PubChem)
1-[1-(3,4-dichlorophenyl)cyclobutyl]-2-(2-oxa-5-azoniabicyclo[2.2.1]heptan-5-yl)ethanol chloride PC
SMILES
C1CC(C1)(C2=CC(=C(C=C2)Cl)Cl)C(C[NH+]3CC4CC3CO4)O.[Cl-] PC
InChIKey
QAHXUHUHCQYFHC-UHFFFAOYSA-N PC
PubChem CID
117903522
IUPAC name
5-(2-(1-(3,4-dichlorophenyl)cyclobutyl)-2-hydroxyethyl)-2-oxa-5-azoniabicyclo WP

Harm reduction information

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Sources

  1. Journal / agency Salamone JD, Correa M, Ferrigno S, Yang JH, Rotolo RA, Presby RE. The Psychopharmacology of Effort-Related Decision Making: Dopamine, Adenosine, and Insights into the Neurochemistry of Motivation. Pharmacol Rev. October 2018. doi:10.1124/pr.117.015107 · PMID 30209181 · PMC6169368
  2. Journal / agency Desibhatla, Mukund. The Development and Evaluation of Novel DA Transport Inhibitors and their Effects on Effort-Related Motivation: A Review. Honors Scholar Theses. 16 June 2021
  3. Journal / agency Yohn SE, Gogoj A, Haque A, Lopez-Cruz L, Haley A, Huxley P, Baskin P, Correa M, Salamone JD. Evaluation of the effort-related motivational effects of the novel dopamine uptake inhibitor PRX-14040. Pharmacol Biochem Behav. September 2016. doi:10.1016/j.pbb.2016.06.004 · PMID 27296079

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.