Compound

Propafenone

Also called GNF-Pf-4594, Norfenon, Pintoform

Original Wikipedia articleen.wikipedia.org/wiki/Propafenone revision used (24 October 2026)

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Overview

Propafenone, sold under the brand name Rythmol among others, is a class 1c anti-arrhythmic medication, which is used to treat illnesses associated with rapid heart beat such as atrial and ventricular arrhythmias. WP

Risks and side effects

Side effects

Side effects attributed to propafenone include hypersensitivity reactions, lupus-like syndrome, agranulocytosis, CNS disturbances such as dizziness, lightheadedness, gastrointestinal upset, a metallic taste and bronchospasm. About 20% of patients discontinued the drug due to side effects. WP

Median lethal dose (LD50) in animals

Quoted from PubChem's Non-Human Toxicity Values, which come from the Hazardous Substances Data Bank (HSDB). PubChem describes them as: “Quantitative non-human toxicity values (e.g., lethal dose) for this compound. The data shown here are mostly for lab animals (e.g., rat, mouse, guinea pig, and rabbit).” and defines the “LD50 (median lethal dose, the estimated amount of a chemical expected to kill 50% of test animals in a single dose)”. PC

LD50 (as the source gives it)	Reference
LD50 Dogt iv 10 mg/kg /Propafenone hydrochloride/ PC	Lewis, R.J. Sr. (ed) Sax's Dangerous Properties of Industrial Materials. 11th Edition. Wiley-Interscience, Wiley & Sons, Inc. Hoboken, NJ. 2004., p. 3060 (via HSDB record 7929)
LD50 Rat iv 18,800 ug/kg /Propafenone hydrochloride/ PC	Lewis, R.J. Sr. (ed) Sax's Dangerous Properties of Industrial Materials. 11th Edition. Wiley-Interscience, Wiley & Sons, Inc. Hoboken, NJ. 2004., p. 3060 (via HSDB record 7929)
LD50 Rat oral 700 mg/kg /Propafenone hydrochloride/ PC	Lewis, R.J. Sr. (ed) Sax's Dangerous Properties of Industrial Materials. 11th Edition. Wiley-Interscience, Wiley & Sons, Inc. Hoboken, NJ. 2004., p. 3060 (via HSDB record 7929)

Pharmacology

Mechanism of action

Propafenone works by slowing the influx of sodium ions into the cardiac muscle cells, causing a decrease in excitability of the cells. Propafenone is more selective for cells with a high rate, but also blocks normal cells more than class Ia or Ib anti-arrhythmic medications. Propafenone differs from the prototypical class Ic antiarrhythmic in that it has additional activity as a beta-adrenergic blocker which can cause bradycardia and bronchospasm. WP

History

Propafenone was approved for use in the United States in November 1989.[1][2] WP

Chemistry

Formula: C21H27NO3 PC
CAS number: 54063-53-5 PC
Molar mass (g/mol): 341.4 PC
IUPAC name (computed by PubChem): 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one PC
SMILES: CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O PC
InChIKey: JWHAUXFOSRPERK-UHFFFAOYSA-N PC
PubChem CID: 4932

Harm reduction information

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Sources

Journal / agency Drugs@FDA: FDA-Approved Drugs
Journal / agency Drug Approval Package: Rythmol SR (Propafenone Hydrochloride) NDA #021416. 2004-05-05

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.