intoxicant.wiki2catechol4school
Beta blocker

Pronethalol

Also called Naphthylisoproterenol, Nethalide, Inetol

Original Wikipedia articleen.wikipedia.org/wiki/Pronethalol revision used (24 October 2026)

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Overview

Pronethalol, sold under the brand name Alderlin, was an early non-selective beta blocker. It was the first beta blocker to be developed by James Black and associates at Imperial Chemical Industries, and the first to enter clinical use, in November 1963.[1] WP

However, it was never used widely due to carcinogenicity in mice, which was thought to result from formation of a carcinogenic naphthalene epoxide metabolite, and was superseded by propranolol from 1965 onward.[1][2] WP

Drug class

Beta blocker WP

From the Wikipedia article's infobox.

Chemistry

Formula
C15H19NO PC
CAS number
54-80-8 PC
Molar mass (g/mol)
229.32 PC
IUPAC name (computed by PubChem)
1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol PC
SMILES
CC(C)NCC(C1=CC2=CC=CC=C2C=C1)O PC
InChIKey
HRSANNODOVBCST-UHFFFAOYSA-N PC
PubChem CID
4930
IUPAC name
1-(naphthalen-2-yl)-2-(propan-2-ylamino)ethanol WP

Harm reduction information

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Pop culture

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Sources

  1. Journal / agency Quirke V. Putting theory into practice: James Black, receptor theory and the development of the beta-blockers at ICI, 1958-1978. Med Hist. January 2006. doi:10.1017/s0025727300009455 · PMID 16502872 · PMC1369014
  2. Journal / agency Stapleton MP. Sir James Black and propranolol. The role of the basic sciences in the history of cardiovascular pharmacology. Texas Heart Institute Journal. 1997. PMID 9456487 · PMC325477

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.