Progesterone
Also called Agolutin, Crinone, Luteol
Dosage
Oral bands as drawn from PsychonautWiki's ranges below. The table is the source of truth.
Oral
| Source | Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|---|
| PsychonautWiki | 100 mg PW | 100–200 mg PW | 200–400 mg PW | 400–600 mg PW | 600 mg+ PW |
Bioavailability: 10% PW
Rectal
| Source | Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|---|
| PsychonautWiki | 100 mg PW | 100–200 mg PW | 200–400 mg PW | 400–600 mg PW | 600 mg+ PW |
What dose are you on? (self-reported, unverified)
No reports yet.
Reports are anonymous, one per browser per day per route. Counts under 20 are shown but marked as too few to mean anything. Until accounts launch, reports stay in this browser only.
Duration
Oral, drawn at the midpoint of each PsychonautWiki range.
| Route · source | Onset | Come-up | Peak | Offset | Total | After-effects |
|---|---|---|---|---|---|---|
| Oral · PsychonautWiki | 30–60 minutes PW | 50–100 minutes PW | 20–40 minutes PW | 20–40 minutes PW | 2–4 hours PW | 4–6 hours PW |
| Rectal · PsychonautWiki | 2–3 hours PW⚠ The source row looks copy-pasted from another route. Check it before relying on it. | – | – | – | 8–12 hours PW | 6–12 hours PW |
Mixing
For best safety practice, don't mix this drug with other depressants.
Why: respiratory depression. PsychonautWiki says:
- “Respiratory depression (also known as hypoventilation) can be described as a reduced urge to breathe that can be fatal depending on its intensity.” (PsychonautWiki, Respiratory depression, revision 150612)
- “... otherwise safe dosages of these compounds can become fatal when combined with even small amounts of other classes of depressant. For example, benzodiazepines combined with opioids are an extremely common cause of fatal respiratory depression. It is therefore strongly discouraged to combine these depressants at any dosage range.” (PsychonautWiki, Respiratory depression, revision 150612)
- “The most common cause of substance-related deaths is the combination of depressants (such as opiates, benzodiazepines, or alcohol) with other depressants.” (PsychonautWiki, Responsible drug use, revision 168206)
- “This combination potentiates the muscle relaxation, amnesia, sedation, and respiratory depression caused by one another. At higher doses, it can lead to a sudden, unexpected loss of consciousness along with a dangerous amount of depressed respiration.” (PsychonautWiki, dangerous interactions table, "Depressants" row, revision 156847)
Quotes from PsychonautWiki, CC BY-SA 4.0.
Acute combinations: what happens when these are taken close together. Entries backed by a medical journal or agency are listed first.
Backed by medical journals
Other documented combinations
- Depressants Taking oral progesterone together with alcohol or barbiturates will increase absorption rates and peak potentially leading to black out intervals or loss of motor control, anesthetic levels in humans are not documented, but might be reachable. Other dangerous depressants are benzodiazepines and opioids since their absorption can be increased, resulting in a higher risk of overdose.[6] PW⚠ PsychonautWiki lists this combination without a danger rating.
Risks and toxicity
Warning: Progesterone is a naturally occuring sex hormone, changing its levels might induce gender dysphoria or premenstrual syndrome. PW
Progesterone has relatively low toxicity relative to dose. PW
It is strongly recommended that one use harm reduction practices when using this substance. PW
Lethal dosage
The observed LD50 in mice was 100mg/kg via intravenous, 327mg/kg intraperitoneal and > 200mg/kg orally, anasthetic effects were observed at 16mg/kg intraperitoneal.[7] PW
Tolerance and addiction potential
Dependence potential of Progesterone has been sparsely reported by transfeminine people. There is one case report of a women on post menopausal HRT that documents addiction.[8] PW
Tolerance to the offects of Progesterone metabolites on GABA will build within a few years and return to baseline within a few months after cessation. PW⚠ PsychonautWiki itself has flagged this text: citation needed.
Interactions
Combining oral progesterone with food leads to a two fold increase in absorptions. Since oral progesterone is a oil soluable reports of increased effects when combined with fatty foods do seem plausible.[9] PW
Testing
Effects
Overview
Pregn-4-ene-3,20-dione, also known as Progesterone or P4 is a steroid sex hormone of the progestogen class. It occurs naturally and is the bodies major progestogen. PW
Progesterone (/proʊˈdʒɛstəroʊn/; P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. It belongs to a group of steroid hormones called the progestogens and is the major progestogen in the body. Progesterone has a variety of important functions in the body. The hormone is also an important metabolic intermediate in the production of other endogenous steroids, including the sex hormones and the corticosteroids, and acts in the brain as a neurosteroid.[1]
In addition to its role as a natural hormone, progesterone is also used as a medication, such as in combination with estrogen for contraception, to reduce the risk of uterine or cervical cancer, in hormone replacement therapy, and in feminizing hormone therapy. It was first prescribed in 1934.[4]
History
History
George W. Corner and Willard M. Allen discovered the hormonal action of progesterone in 1929. By 1931–1932, nearly pure crystalline material of high progestational activity had been isolated from the corpus luteum of animals; by 1934, pure crystalline progesterone had been refined and obtained, and the chemical structure of progesterone was determined. This was achieved by Adolf Butenandt at the Chemisches Institut of Gdańsk Technical University in Danzig, who extracted this new compound from several thousand liters of urine.[10–14] WP
Chemical synthesis of progesterone from stigmasterol and pregnanediol was accomplished later that year. Up to this point, progesterone, known generically as corpus luteum hormone, had been being referred to by several groups by different names, including corporin, lutein, luteosterone, and progestin. In 1935, at the time of the Second International Conference on the Standardization of Sex Hormones in London, England, a compromise was reached between the groups, and the name 'progesterone' (progestational steroidal ketone) was created.[10]
Pricing
Pricing for progesterone can vary depending location, insurance coverage, discount coupons, quantity, shortages, manufacturers, brand or generic versions, different pharmacies, and so on. As of 2023, 30 capsules of 100 mg of the generic version, Progesterone, from CVS Pharmacy is around $40 without any discounts or insurance applied. The brand version, Prometrium, is around $450 for 30 capsules without any discounts or insurance applied. In comparison, Walgreens offers 30 capsules of 100 mg in the generic version for $51 without insurance or coupons applied. The brand name costs around $431 for 30 capsules of 100 mg.[18] WP
Legal status
Pharmacology
Chemistry
- Formula
- C21H30O2 PC
- CAS number
- 57-83-0 PC
- Molar mass (g/mol)
- 314.5 PC
- IUPAC name (computed by PubChem)
- (8S,
9S, PC10R, 13S, 14S, 17S) - 17- acetyl- 10, 13- dimethyl- 1, 2, 6, 7, 8, 9, 11, 12, 14, 15, 16, 17- dodecahydrocyclopenta[a] phenanthren- 3- one - SMILES
- CC(=O)
[C@H] PC1CC[C@@H] 2[C@@] 1(CC[C@H] 3[C@H] 2CCC4=CC(=O) CC[C@] 34C) C - InChIKey
- RJKFOVLPORLFTN-
LEKSSAKUSA- PCN - PubChem CID
- 5994
User reports
Erowid erowid.org
ListingsBluelight bluelight.org
ListingsReddit reddit.com
ListingsPop culture
No references added yet.
Add a reference
Registered users can add songs, films, books, shows, games and art about this substance. Link a source that names the substance, such as the work's Wikipedia article, a review or an interview, not only the work itself. Entries are voted on and moderated like every other value on this page.
Opens when accounts launch.
References
- Other Jameson JL, De Groot LJ. Endocrinology: Adult and Pediatric E-Book. 25 February 2015
- Other King TL, Brucker MC. Pharmacology for Women's Health. 25 October 2010
- Journal / agency Baulieu E, Schumacher M. Progesterone as a neuroactive neurosteroid, with special reference to the effect of progesterone on myelination. Steroids. 2000. doi:10.1016/s0039-128x(00)00173-2 · PMID 11108866
- Journal / agency Prior JC. Progesterone Is Important for Transgender Women's Therapy-Applying Evidence for the Benefits of Progesterone in Ciswomen. The Journal of Clinical Endocrinology and Metabolism. April 2019. doi:10.1210/jc.2018-01777 · PMID 30608551
- Other Fischer J, Ganellin CR. Analogue-based Drug Discovery. 2006
- Harm reduction site Progesterone: Uses, Interactions, Mechanism of Action. 2016-04-13
- Other EVIDENCE ON THE DEVELOPMENTAL AND REPRODUCTIVE TOXICITY OF Progesterone
- Journal / agency &Na;. Progesterone abuse Adverse effects: case report. Reactions Weekly. 1996. doi:10.2165/00128415-199605990-00031
- Journal / agency Simon, James A.; Robinson, Denise E.; Andrews, Mason C.; Hildebrand, James R.; Rocci, Mario L.; Blake, Richard E.; Hodgen, Gary D. The absorption of oral micronized progesterone: the effect of food, dose proportionality, and comparison with intramuscular progesterone. Fertility and Sterility. 1993. doi:10.1016/S0015-0282(16)56031-2
- Other Josimovich JB. Gynecologic Endocrinology. 11 November 2013
- Journal / agency Corner GW, Allen WM. Physiology of the corpus luteum. American Journal of Physiology. Legacy Content. 1 March 1929. doi:10.1152/ajplegacy.1929.88.2.326
- Other Coutinho EM, Segal SJ. Is Menstruation Obsolete?. 1999
- Other Walker A. The Menstrual Cycle. 7 March 2008
- Journal / agency Piosik R. Adolf Butenandt und sein Wirken an der Technischen Hochschule Danzig. CHEMKON. 2003. doi:10.1002/ckon.200390038
- Other Ginsburg B. Premenstrual Syndrome: Ethical and Legal Implications in a Biomedical Perspective. 6 December 2012
- Other Rolleston HD. The Endocrine Organs in Health and Disease: With an Historical Review. 1936
- Journal / agency Allen WM. Progesterone: how did the name originate?. Southern Medical Journal. October 1970. doi:10.1097/00007611-197010000-00012 · PMID 4922128
- Other Progesterone Prices, Coupons & Savings Tips - GoodRx
- Other Progesterone (International database). 2024-03-03
Text and values on this page are quoted from PsychonautWiki (CC BY-SA 4.0), Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.