Perphenazine enanthate
Overview
Perphenazine enanthate, sold under the brand name Trilafon Enantat among others, is a typical antipsychotic and a depot antipsychotic ester which is used in the treatment of schizophrenia and has been marketed in Europe. It is formulated in sesame oil and administered by intramuscular injection and acts as a long-lasting prodrug of perphenazine. Perphenazine enanthate is used at a dose of 25 to 200 mg once every 2 weeks by injection, with a time to peak levels of 2 to 3 days and an elimination half-life of 4 to 7 days.[1–6] WP
Drug class
Typical antipsychotic WP
From the Wikipedia article's infobox.
Chemistry
- Formula
- C28H38ClN3O2S PC
- CAS number
- 17528-28-8 PC
- Molar mass (g/mol)
- 516.1 PC
- IUPAC name (computed by PubChem)
- 2-
[4- PC[3- (2- chlorophenothiazin- 10- yl) propyl] piperazin- 1- yl] ethyl heptanoate - SMILES
- CCCCCCC(=O)
OCCN1CCN(CC1) PCCCCN2C3=CC=CC=C3SC4=C2C=C(C=C4) Cl - InChIKey
- PWEGQJCIAMJJHC-
UHFFFAOYSA- PCN - PubChem CID
- 62871
Harm reduction information
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Sources
- Other Swiss Pharmaceutical Society. Index Nominum 2000: International Drug Directory. 2000
- Journal / agency Altamura AC, Sassella F, Santini A, Montresor C, Fumagalli S, Mundo E. Intramuscular preparations of antipsychotics: uses and relevance in clinical practice. Drugs. 2003. doi:10.2165/00003495-200363050-00004 · PMID 12600227
- Journal / agency Davis JM, Matalon L, Watanabe MD, Blake L, Metalon L. Depot antipsychotic drugs. Place in therapy. Drugs. May 1994. doi:10.2165/00003495-199447050-00004 · PMID 7520856
- Journal / agency Taylor D. Psychopharmacology and adverse effects of antipsychotic long-acting injections: a review. Br J Psychiatry Suppl. November 2009. doi:10.1192/bjp.195.52.s13 · PMID 19880912
- Journal / agency Spanarello S, La Ferla T. The pharmacokinetics of long-acting antipsychotic medications. Curr Clin Pharmacol. 2014. doi:10.2174/15748847113089990051 · PMID 23343447
- Journal / agency De Risio A, Lang AP. History and therapeutic rationale of long acting antipsychotics. Curr Clin Pharmacol. February 2014. doi:10.2174/15748847113089990057 · PMID 23343446
Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.