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Substance

Olmesartan/hydrochlorothiazide

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Overview

Olmesartan/hydrochlorothiazide, sold under the brand name Benicar HCT among others, is a fixed-dose combination medication used to treat high blood pressure. It is a combination of olmesartan medoxomil, an angiotensin II receptor blocker and hydrochlorothiazide, a diuretic. It may be used if olmesartan is not sufficient to manage blood pressure. It is taken by mouth.[1][2][3] WP

Common side effects include nausea, dizziness, and upper respiratory tract infections. Serious side effects may include kidney problems, allergic reactions, electrolyte problems and low blood pressure. Use in pregnancy is not recommended. Olmesartan works by blocking the effects of angiotensin II while hydrochlorothiazide works by increasing the loss of sodium by the kidneys.[1] WP

No generic version is available in the United States as of 2017. In 2022, it was the 235th most commonly prescribed medication in the United States, with more than 1 million prescriptions.[2][4][5] WP

Chemistry

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Harm reduction information

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Sources

  1. Journal / agency Benicar HCT- olmesartan medoxomil-hydrochlorothiazide tablet, film coated. 7 September 2022
  2. Other Bope ET, Kellerman RD. Conn's Current Therapy 2017 E-Book. 2016
  3. Other British national formulary: BNF 76. 2018
  4. Other The Top 300 of 2022
  5. Other Hydrochlorothiazide; Olmesartan Drug Usage Statistics, United States, 2013 - 2022

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