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Substance

Olanzapine/samidorphan

Original Wikipedia articleen.wikipedia.org/wiki/Olanzapine/samidorphan revision used (24 October 2026)

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Overview

Olanzapine/samidorphan, sold under the brand name Lybalvi, is a fixed-dose combination medication for the treatment of schizophrenia and bipolar I disorder. It contains olanzapine, an atypical antipsychotic, and samidorphan, an opioid antagonist. Samidorphan reduces the weight gain associated with olanzapine while still allowing olanzapine to exert its therapeutic effect. The formulation was approved for medical use in the United States in May 2021.[1–6] WP

Chemistry

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Harm reduction information

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Sources

  1. Journal / agency Lybalvi- olanzapine and samidorphan l-malate tablet, film coated. 24 February 2022
  2. Journal / agency Maric NP, Jovicic MJ, Mihaljevic M, Miljevic C. Improving Current Treatments for Schizophrenia. Drug Development Research. 2016. doi:10.1002/ddr.21337 · PMID 27633376
  3. Journal / agency Fellner C. New Schizophrenia Treatments Address Unmet Clinical Needs. P T. 2017. PMID 28163559 · PMC5265239
  4. Journal / agency Citrome L, Graham C, Simmons A, Jiang Y, Todtenkopf MS, Silverman B, DiPetrillo L, Cummings H, Sun L, McDonnell D. An Evidence-Based Review of OLZ/SAM for Treatment of Adults with Schizophrenia or Bipolar I Disorder. Neuropsychiatr Dis Treat. 2021. doi:10.2147/NDT.S313840 · PMID 34526769 · PMC8437420
  5. Journal / agency Paik J. Olanzapine/Samidorphan: First Approval. Drugs. August 2021. doi:10.1007/s40265-021-01568-0 · PMID 34304374
  6. Journal / agency Drug Approval Package: Lybalvi. 26 June 2021

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