intoxicant.wiki2catechol4school
Compound

Norwogonin

Also called 5,7,8-Trihydroxyflavone, 5,7,8-hydroxyflavone

Original Wikipedia articleen.wikipedia.org/wiki/Norwogonin revision used (24 October 2026)

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Overview

Norwogonin, also known as 5,7,8-trihydroxyflavone (5,7,8-THF), is a flavone, a naturally occurring flavonoid-like chemical compound which is found in Scutellaria baicalensis (Baikal skullcap). It has been found to act as an agonist of the TrkB, the main signaling receptor of brain-derived neurotrophic factor (BDNF), and appears to possess roughly the same activity in this regard to that of the closely related but more well-known tropoflavin (7,8-DHF).[1][2] WP

Chemistry

Formula
C15H10O5 PC
CAS number
4443-09-8 PC
Molar mass (g/mol)
270.24 PC
IUPAC name (computed by PubChem)
5,7,8-trihydroxy-2-phenylchromen-4-one PC
SMILES
C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C=C3O)O)O PC
InChIKey
ZFKKRRMUPBBYRS-UHFFFAOYSA-N PC
PubChem CID
5281674
IUPAC name
5,7,8-trihydroxy-2-phenylchromen-4-one WP

Harm reduction information

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Sources

  1. Journal / agency Miyasaki Y, Rabenstein JD, Rhea J, Crouch ML, Mocek UM, Kittell PE, Morgan MA, Nichols WS, Van Benschoten MM, Hardy WD, Liu GY. Isolation and characterization of antimicrobial compounds in plant extracts against multidrug-resistant Acinetobacter baumannii. PLOS ONE. 2013. doi:10.1371/journal.pone.0061594 · PMID 23630600 · PMC3632535
  2. Journal / agency Liu X, Chan CB, Jang SW, Pradoldej S, Huang J, He K, Phun LH, France S, Xiao G, Jia Y, Luo HR, Ye K. A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect. Journal of Medicinal Chemistry. December 2010. doi:10.1021/jm101206p · PMID 21073191 · PMC3150605

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.