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Selective serotonin 5-HT2A receptor agonist · Serotonergic psychedelic · Hallucinogen

LPH-48

Original Wikipedia articleen.wikipedia.org/wiki/LPH-48 revision used (24 October 2026)

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Overview

LPH-48 is a selective serotonin 5-HT2A receptor agonist and psychedelic hallucinogen which is under development for the treatment of alcoholism. Its route of administration has not been specified.[1][2][3] WP

The drug acts as a selective agonist of the serotonin 5-HT2A receptor. It is said to be an analogue of LPH-5 with similar characteristics but with faster metabolism and a shorter duration of action. LPH-5 is a highly selective serotonin 5-HT2A receptor agonist that is under development for major depressive disorder and has shown antidepressant-like effects in animals.[1–6] WP

LPH-48 is under development by Lophora. As of May 2024, it is in preclinical research for alcoholism. The chemical structure of LPH-48 does not yet seem to have been disclosed. However, Lophora has patented selective serotonin 5-HT2A receptor agonists for treatment of depression and the company is said to have patent protection for LPH-48. Additionally, the structure of its close analogue LPH-5 is known and this compound is a phenylpiperidine derivative.[1][2][4][7] WP

Drug class

Selective serotonin 5-HT2A receptor agonist Serotonergic psychedelic Hallucinogen WP

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Chemistry

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Sources

  1. Journal / agency LPH 48. 22 May 2024
  2. Other Delving into the Latest Updates on LPH-48 with Synapse. 19 September 2024
  3. Other Lophora. Lophora Submits Clinical Trial Authorisation (CTA) Application to the French Medicines Agency (ANSM) for Lead CNS Drug LPH-5. 31 May 2024
  4. Journal / agency M Ro Rsted E, Jensen AA, Smits G, Frydenvang K, Kristensen JL. Discovery and Structure-Activity Relationships of 2,5-Dimethoxyphenylpiperidines as Selective Serotonin 5-HT2A Receptor Agonists. Journal of Medicinal Chemistry. May 2024. doi:10.1021/acs.jmedchem.4c00082 · PMID 38648420 · PMC11089506
  5. Journal / agency LPH 5. 7 March 2023
  6. Other Jensen AA, Cecchi CR, Hibicke M, Bach AH, Kaadt E, Marcher-Rorsted E, Nichols CD, Elfving B, Kristensen JL. The selective 5-HT2Areceptor agonist LPH-5 induces persistent and robust antidepressant-like effects in rodents. 22 April 2024
  7. Other 5-HT2A agonists for use in treatment of depression

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