Depressant

Kanna

Original Wikipedia articleNot linked yet. It gets linked once the exact article is confirmed.

Common dose · Insufflated20–50 mg TS

Dosage

Insufflated

Source	Threshold	Light	Common	Strong	Heavy
TripSit	–	10–20 mg TS	20–50 mg TS	50–150 mg+ TS	–

Oral

Source	Threshold	Light	Common	Strong	Heavy
TripSit	–	250–500 mg TS	500–1000 mg TS	1000–2000 mg TS	–

Vapourized

Source	Threshold	Light	Common	Strong	Heavy
TripSit	–	30–50 mg TS	50–100 mg TS	100–250 mg. TS	–

Note: We recommend against insufflating this substance, it is extremely painful and damaging to the nasal cavity. TS

TripSit dose text

TripSit's factsheet also states its doses as text.

Oral Light: 250-500mg Common: 500-1000mg Strong: 1000-2000mg | Insufflated Light: 10-20mg Common: 20-50mg Strong: 50-150mg+ | Vapourized Light: 30-50mg Common: 50-100mg Strong: 100-250mg. | Note: We recommend against insufflating this substance, it is extremely painful and damaging to the nasal cavity. TS

What dose are you on? (self-reported, unverified)

Read this first. These numbers come from anonymous visitors typing in a box. Nobody checks them. People misjudge, mistype, troll, or take untested products of unknown strength. They are not a dose guide and never override the sourced table above. They exist only so the sourced ranges can be compared with what people say they take. If you are deciding what to take, use the sourced table, start low, and read the risks section.

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Duration

TripSit factsheet

Onset: Insufflated: 5-10 minutes · Oral: 30-90 minutes · Smoked: 1-2 minutes TS
Duration: Insufflated: 60-150 minutes · Oral: 180-360 minutes · Vapourized: 90-150 minutes TS
Aftereffects: 1-8 hours TS

Mixing

For best safety practice, don't mix this drug with other depressants.

Why: respiratory depression. PsychonautWiki says:

“Respiratory depression (also known as hypoventilation) can be described as a reduced urge to breathe that can be fatal depending on its intensity.” (PsychonautWiki, Respiratory depression, revision 150612)
“... otherwise safe dosages of these compounds can become fatal when combined with even small amounts of other classes of depressant. For example, benzodiazepines combined with opioids are an extremely common cause of fatal respiratory depression. It is therefore strongly discouraged to combine these depressants at any dosage range.” (PsychonautWiki, Respiratory depression, revision 150612)
“The most common cause of substance-related deaths is the combination of depressants (such as opiates, benzodiazepines, or alcohol) with other depressants.” (PsychonautWiki, Responsible drug use, revision 168206)
“This combination potentiates the muscle relaxation, amnesia, sedation, and respiratory depression caused by one another. At higher doses, it can lead to a sudden, unexpected loss of consciousness along with a dangerous amount of depressed respiration.” (PsychonautWiki, dangerous interactions table, "Depressants" row, revision 156847)

Quotes from PsychonautWiki, CC BY-SA 4.0.

Acute combinations: what happens when these are taken close together. Entries backed by a medical journal or agency are listed first.

Backed by medical journals

Awaiting sourcePeer-reviewed reports on acute combinations, from PubMed and the journals the harm reduction sites cite.

Risks and toxicity

TripSit factsheet

Avoid: Other CNS depressants. TS

Testing

Awaiting sourceReagent reactions and test kit guidance from a harm reduction testing service.

Effects

Awaiting sourceSubjective and physical effects from PsychonautWiki or TripSit.

Overview

A South African plant containing numerous psychoactive alkaloids, including mesembrine and mesembrenone. The first written account of the substance was in 1662. The pharmacology of these compounds is poorly understood, but they are suspected to be serotonin uptake inhibitors and potentially monoamine releasers. Said to suppress appetite, produce mild euphoria and reduce anxiety. TS

History

Awaiting sourceHistory and culture from Wikipedia or PsychonautWiki, with their citations.

Legal status

Awaiting sourceLegal status by country from Wikipedia or PsychonautWiki.

Pharmacology

Awaiting sourcePharmacology from Wikipedia and the journal papers it cites.

Chemistry

Awaiting sourceFormula, structure and identifiers from PubChem.

User reports

Erowid erowid.org

Listings

Awaiting sourceExperience Vault listing and report categories.

Bluelight bluelight.org

Listings

Awaiting sourceTrip report threads and this substance's discussion forum.

Reddit reddit.com

Listings

Awaiting sourceTrip report posts and the relevant subreddits.

Pop culture

No references added yet.

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References

This page cites its source pages directly. None of them listed further references for the values shown.

Text and values on this page are quoted from TripSit factsheets. Each value links to the exact revision it came from.