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Biologic

Certolizumab pegol

Original Wikipedia articleen.wikipedia.org/wiki/Certolizumab_pegol revision used (24 October 2026)

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Overview

Certolizumab pegol, sold under the brand name Cimzia, is a biopharmaceutical medication for the treatment of Crohn's disease, rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. It is a fragment of a monoclonal antibody specific to tumor necrosis factor alpha (TNF-α) and is manufactured by UCB.[1–5] WP

Certolizumab pegol is a therapeutic alternative on the World Health Organization's List of Essential Medicines.[6] WP

Uses, dosage and effects

Medical uses

Crohn's Disease: On April 22, 2008, the U.S. Food and Drug Administration (FDA) approved Cimzia for the treatment of Crohn's disease in people who did not respond sufficiently or adequately to standard therapy.[4][7][8] WP

Rheumatoid arthritis: On June 26, 2009, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) issued a positive opinion recommending that the European Commission grant a marketing authorisation for Cimzia for the treatment of rheumatoid arthritis only - the CHMP refused approval for the treatment of Crohn's disease. The marketing authorisation was granted to UCB Pharma SA in October 2009.[9] WP

Psoriatic arthritis: On September 27, 2013, the U.S. FDA approved Cimzia for the treatment of adult patients with active psoriatic arthritis.[10] WP

Chemistry

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Harm reduction information

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Sources

  1. Journal / agency Sandborn WJ, Feagan BG, Stoinov S, Honiball PJ, Rutgeerts P, Mason D, Bloomfield R, Schreiber S. Certolizumab pegol for the treatment of Crohn's disease. The New England Journal of Medicine. July 2007. doi:10.1056/NEJMoa067594 · PMID 17634458 · PMC3187683
  2. Journal / agency Goel N, Stephens S. Certolizumab pegol. mAbs. 2010. doi:10.4161/mabs.2.2.11271 · PMID 20190560 · PMC2840232
  3. Journal / agency Kaushik VV, Moots RJ. CDP-870 (certolizumab) in rheumatoid arthritis. Expert Opinion on Biological Therapy. April 2005. doi:10.1517/14712598.5.4.601 · PMID 15934837
  4. Journal / agency Drug Approval Package: Cimzia (Certolizumab Pegol) NDA #125160. December 24, 1999
  5. Journal / agency Cimzia- certolizumab pegol kit Cimzia- certolizumab pegol injection, solution. April 24, 2020
  6. Journal / agency The selection and use of essential medicines, 2025: WHO Model List of Essential Medicines, 24th list. 2025. doi:10.2471/B09474
  7. Other Cimzia Approved in the US for the Treatment of Moderate to Severe Crohn's Disease
  8. Other Waknine Y. FDA Approvals: Patanase, Actonel, Cimzia. May 1, 2008
  9. Journal / agency Cimzia EPAR. October 22, 2009
  10. Other Cimzia (certolizumab pegol) approved by the U.S. FDA for treatment of adult patients with active psoriatic arthritis

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