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Plant or preparation · Deliriant

Datura

Also called Jimson Weed

Original Wikipedia articleen.wikipedia.org/wiki/Datura revision used (24 October 2026)

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Onset20–120 minutes PW
Total8–18 hours PW
After-effects6–24 hours PW

Dosage

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Duration

Route · sourceOnsetCome-upPeakOffsetTotalAfter-effects
Oral · PsychonautWiki20–120 minutes PW60–120 minutes PW5–12 hours PW2–3 hours PW8–18 hours PW6–24 hours PW

TripSit factsheet

Onset
60-120 minutes TS
Duration
12-72+ hours TS
Aftereffects
24-72 hours TS

Mixing

Acute combinations: what happens when these are taken close together. Entries backed by a medical journal or agency are listed first.

Backed by medical journals

Awaiting sourcePeer-reviewed reports on acute combinations, from PubMed and the journals the harm reduction sites cite.

Risks and toxicity

Datura is known to be extremely unpredictable and has the potential to result in severe consequences, hospitalization or death. The toxicity and long-term health effects of regular datura usage do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because long-term datura usage is very rare and the vast majority of people who try it do not desire to repeat the experience. PW

In traditional cultures, a great deal of experience with and detailed knowledge of datura was critical to minimize harm. Many fatal incidents result from modern users ingesting datura. For example, in the 1990s and 2000s, the United States media contained stories of adolescents and young adults dying or becoming seriously ill from intentionally ingesting datura. There are also several reports in the medical literature of deaths from D. stramonium and D. ferox intoxication. Children are especially vulnerable to atropine poisoning and their prognosis is likely to be fatal.[12–20] PW

In some parts of Europe and India, datura has been a popular poison for suicide and murder. From 1950 to 1965, the State Chemical Laboratories in Agra, India investigated 2,778 deaths caused by ingesting datura.[12][13][21] PW

Psychosis

Datura has been reported to cause psychosis and delirium at a significantly higher rate than other hallucinogens like LSD, ketamine, or DMT. There are a large number of experience reports online which describe states of psychotic delirium, amnesia, and other serious consequences after abusing the drug. In many cases, it has resulted in hospitalization and death. PW

Lethal dosage

There can be a 5:1 potency variation between plants and a given plant's toxicity depends on its age, where it is growing, and the local weather conditions. This variation makes datura exceptionally hazardous as a drug and there is no way for the common man to accurately measure the dosage of any given plant. Datura has been used for centuries in some cultures as a poison because of the presence of these substances.[12][13] PW

The safest way to prevent overdose is to grind the dried plant matter into an extremely fine and even powder so that the active chemicals within them are distributed evenly across itself. From here, one can slowly work their way up in extremely small increments until the correct dose for that particular plant is found. PW

It is strongly advised that one avoid using datura altogether. Otherwise, extreme caution and harm reduction practices should be used, such as having a sober and prepared trip sitter present throughout the experience. PW

Tolerance and addiction potential

The use of datura can be considered mildly addictive with a high potential for adverse side effects such as psychosis. Datura is reported to be significantly less addictive than than other substances because the vast majority of people who try it do not wish to repeat the experience. PW

Tolerance to many of the effects of datura develops with repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). Datura presents cross-tolerance with deliriants, meaning that after the consumption of datura, all deliriants will have a reduced effect. PW

TripSit factsheet

Avoid
Yes. Just avoid it. TS
Warning
Datura can be incredibly dangerous, dosing can be hard to determine and caution should be used. In general this drug should be avoided. TS

Testing

Awaiting sourceReagent reactions and test kit guidance from a harm reduction testing service.

Effects

surreal interactions with worldhallucinationsdry mouthnauseafearanxietyamnesiadifficulty breathingconfusiondelirium TS

Overview

Datura (also known as devil's trumpet, moonflower, jimsonweed, devil's weed, hell's bells, thorn-apple, and many others) is a genus of nine species of poisonous flowering plants belonging to the family Solanaceae. Datura is known as a powerful and dangerous deliriant, used for shamanic and medical purposes, as well as poisons. They contain the potent anticholinergic substances scopolamine, hyoscyamine, and atropine primarily in their seeds and flowers.[1] PW

A family of plants containing various Tropane alkaloids. Produces long-lasting deliriant effects including very realistic and often unpleasant hallucinations along with short-term amnesia. Datura plants are toxic to humans, and potency varies greatly from plant-to-plant, making the drug extremely difficult to dose safely. Not typically regarded as recreational. TS

Datura is a genus of nine species of highly poisonous, vespertine-flowering plants belonging to the nightshade family (Solanaceae). They are commonly known as thornapples or jimsonweeds, but are also known as devil's trumpets or mad apple (not to be confused with angel's trumpets, which are placed in the closely related genus Brugmansia). Other English common names include moonflower, devil's weed and hell's bells. All species of Datura are extremely poisonous and psychoactive, especially their seeds and flowers, which can cause respiratory depression, arrhythmias, fever, delirium, hallucinations, anticholinergic toxidrome, psychosis, and death if taken internally.[2][3][4] WP

The name Datura originates from the Sanskrit word for "thorn-apple," with historical and cultural significance in Ayurveda and Hinduism, while the American term "jimsonweed" derives from its prevalence in Jamestown, Virginia, where it was called "Jamestown-Weed." Datura species are herbaceous annual or short-lived perennial plants up to two meters tall with trumpet-shaped flowers and spiny fruit capsules, historically used in traditional medicine, especially in India, where they hold cultural and ritual significance. Datura species classification is complex due to high variability and overlapping traits among species, with many "new species" later reclassified as local varieties or subspecies; most species are native to Mexico, though some have disputed native ranges outside the Americas. Datura is closely related to Brugmansia and the recently established Trompettia. WP

Due to their effects and symptoms, Datura species have occasionally been used not only as poisons, but also as hallucinogens by various groups throughout history. Traditionally, their psychoactive administration has often been associated with witchcraft and sorcery or similar practices in many cultures, including the Western world. Certain common Datura species have also been used ritualistically as entheogens by some Native American groups.[5–10] WP

Non-psychoactive use of plants in the genus is usually done for medicinal purposes, and the alkaloids present in some species have long been considered traditional medicines in both the New and Old Worlds due to the presence of the alkaloids scopolamine and atropine, which are also produced by plants associated with Old World medicine such as Hyoscyamus niger, Atropa belladonna and Mandragora officinarum.[5][6][11] WP

History

Awaiting sourceHistory and culture from Wikipedia or PsychonautWiki, with their citations.

Pharmacology

Awaiting sourcePharmacology from Wikipedia and the journal papers it cites.

Chemistry

Awaiting sourceFormula, structure and identifiers from PubChem.

User reports

Erowid erowid.org

Listings

Erowid Experience Vault listing

Link as published on TripSit's factsheet.

Top stories
Awaiting sourceShort summaries of the most-read reports, each linked, saying only what the report says.

Bluelight bluelight.org

Listings
Awaiting sourceTrip report threads and this substance's discussion forum.
Top stories
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Reddit reddit.com

Listings
Awaiting sourceTrip report posts and the relevant subreddits.
Top stories
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Pop culture

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References

  1. Journal / agency Freye, E. Toxicity of Datura Stramonium. 2010. doi:10.1007/978-90-481-2448-0_34
  2. Other 1959 Avery, Amos Geer, Satina, Sophie and Rietsema, Jacob Blakeslee: the genus Datura, foreword and biographical sketch by Edmund W. Sinnott, pub. New York: Ronald Press Co
  3. Other Datura metel
  4. Journal / agency Trancă, S. D.; Szabo, R.; Cociş, M. Acute poisoning due to ingestion of Datura stramonium – a case report. Romanian Journal of Anaesthesia and Intensive Care. 2017. doi:10.21454/rjaic.7518.241.szb · PMID 28913501 · PMC5555431
  5. Journal / agency Fatur, Karsten. 'Hexing Herbs' in Ethnobotanical Perspective: A Historical Review of the Uses of Anticholinergic Solanaceae Plants in Europe. Economic Botany. June 2020. doi:10.1007/s12231-020-09498-w
  6. Other Kennedy, David O. Plants and the Human Brain. 2014
  7. Other Hansen, Harold A. The Witch's Garden pub. Unity Press 1978 ISBN 978-0-913300-47-3
  8. Other Rätsch, Christian, The Encyclopedia of Psychoactive Plants: Ethnopharmacology and Its Applications pub. Park Street Press 2005
  9. Other Garcia, Cecilia; Adams, James D. (2005). Healing with medicinal plants of the west – cultural and scientific basis for their use. Abedus Press ISBN 0-9763091-0-6
  10. Other Smith, Gordon. The Kumeyaay rock art at Hakwin: Hallucinogen datura explains symbols. 15 December 1983
  11. Other Schultes, Richard Evans; Hofmann, Albert (1979). The Botany and Chemistry of Hallucinogens (2nd ed.). Springfield Illinois: Charles C. Thomas
  12. Other Preissel, U., Preissel, H.-G. Brugmansia and Datura: angel’s trumpets and thorn apples. 2005
  13. Journal / agency Adams, J. D., Garcia, C. Spirit, Mind and Body in Chumash Healing. Evidence-based Complementary and Alternative Medicine. December 2005. doi:10.1093/ecam/neh130
  14. Journal / agency Suspected Moonflower Intoxication --- Ohio, 2002
  15. Other Jimson weed users chase high all the way to hospital - USATODAY.com
  16. Journal / agency Michalodimitrakis, M., Koutselinis, A. Discussion of “Datura stramonium: a fatal poisoning”. Journal of Forensic Sciences. October 1984
  17. Journal / agency Boumba, V. A., Mitselou, A., Vougiouklakis, T. Fatal poisoning from ingestion of Datura stramonium seeds. Veterinary and Human Toxicology. April 2004
  18. Journal / agency Steenkamp, P. A., Harding, N. M., Heerden, F. R. van, Wyk, B.-E. van. Fatal Datura poisoning: identification of atropine and scopolamine by high performance liquid chromatography/photodiode array/mass spectrometry. Forensic Science International. October 2004. doi:10.1016/j.forsciint.2004.03.011
  19. Journal / agency Taha, S. A., Mahdi, A. H. Datura intoxication in Riyadh. Transactions of the Royal Society of Tropical Medicine and Hygiene. 1984. doi:10.1016/0035-9203(84)90196-2
  20. Journal / agency Djibo, A., Bouzou, S. B. Acute intoxication with “sobi-lobi” (Datura). Four cases in Niger. Bulletin De La Societe De Pathologie Exotique (1990). November 2000
  21. Other Andrews, D. Daturas
  22. Other Article (artigo) 33, Lei nº 11.343 of 23/8/2006, referring to chart E (lista E) of the Portaria SVS/MS nº 344 of 12/5/1998, last amended by Resolução de Diretoria Colegiada - RDC nº 835 of 13/12/2023, as of 29/2/2024. link 2
  23. Other Psychoactive Substances Act 2016

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