Aleph
Also called Dot, Para-dot
Dosage
Oral
TripSit dose text
TripSit's factsheet also states its doses as text.
Oral Light: 2-4mg Common: 4-6mg Strong: 6-12mg. TS
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Duration
TripSit factsheet
Mixing
Acute combinations: what happens when these are taken close together. Entries backed by a medical journal or agency are listed first.
Backed by medical journals
Risks and toxicity
TripSit factsheet
- Avoid
- All other drugs as this is a one of kind. TS
Testing
Effects
Shulgin notes
These figures come from the Shulgins' own small trials, published decades ago. They are history, not a dosing guide: they were never checked the way a harm reduction dose table is, and batches, purity and people differ.
Read entry #3 in Erowid's online library
From PiHKAL and TiHKAL by Alexander and Ann Shulgin, as tabulated in Wikipedia's articles on the books (CC BY-SA 4.0). The books' text belongs to the Shulgins, so only the listed figures and a link are given here. Synthesis details are never shown on this site.
Overview
The first sulphur-containing Phenethylamine to have been evaluated for CNS activity for Stimulant or Psychedelic purposes. TS
Aleph, or ALEPH-1, also known as DOT or para-DOT or as 4-methylthio-2,5-dimethoxyamphetamine, is a psychedelic drug of the phenethylamine, amphetamine, and DOx families. It is one of the Aleph series of compounds.[1] WP
History
History
Aleph was first tested by Alexander Shulgin in 1975. It was first described in the scientific literature by Shulgin and David E. Nichols in 1976. Its properties and effects in humans were described by them in 1978. Subsequently, the drug was described in greater detail by Shulgin in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved).[1–4] WP
Legal status
Names
Aleph was named by Alexander Shulgin, who named it after the first letter of the Hebrew alphabet. Another earlier name of the drug is para-DOT.[1]
Canada
Aleph is a controlled substance in Canada under phenethylamine blanket-ban language.[5] WP
United states
In the United States, Aleph is a Schedule 1 controlled substance as a positional isomer of 2C-T-4 and 2C-T-7.[6] WP
Pharmacology
Pharmacodynamics
Aleph is known to be a superagonist of the serotonin 5-HT2A receptor (EC₅₀ (half-maximal effective concentration) = 10–66 nM; Eₘₐₓ (maximal efficacy) = 114–191%).[7]
It has weak MAO-A inhibitory activity with an IC₅₀ (half-maximal inhibitory concentration) of 5.2 μM. For comparison, amphetamine has an IC₅₀ of 11 μM and 4-methylthioamphetamine (4-MTA) has a value of 0.2 μM.[9] WP
Chemistry
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References
- Harm reduction site CitePiHKAL
- Journal / agency Nichols DE, Shulgin AT. Sulfur analogs of psychotomimetic amines. J Pharm Sci. October 1976. doi:10.1002/jps.2600651040 · PMID 978423
- Journal / agency Jacob P, Anderson G, Meshul CK, Shulgin AT, Castagnoli N. Monomethylthio analogues of 1-(2,4,5-trimethoxyphenyl)-2-aminopropane. J Med Chem. October 1977. doi:10.1021/jm00220a001 · PMID 903913
- Journal / agency Shulgin AT, Nichols DE. The Psychopharmacology of Hallucinogens. 1978. doi:10.1016/b978-0-08-021938-7.50010-2
- Other Controlled Drugs and Substances Act
- Other Lists of: Scheduling Actions Controlled Substances Regulated Chemicals. January 2023
- Journal / agency Halberstadt AL, Luethi D, Hoener MC, Trachsel D, Brandt SD, Liechti ME. Use of the head-twitch response to investigate the structure-activity relationships of 4-thio-substituted 2,5-dimethoxyphenylalkylamines. Psychopharmacology. January 2023. doi:10.1007/s00213-022-06279-2 · PMID 36477925 · PMC9816194
- Journal / agency Pottie E, Poulie CB, Simon IA, Harpsøe K, D'Andrea L, Komarov IV, Gloriam DE, Jensen AA, Kristensen JL, Stove CP. Structure-Activity Assessment and In-Depth Analysis of Biased Agonism in a Set of Phenylalkylamine 5-HT2A Receptor Agonists. ACS Chem Neurosci. August 2023. doi:10.1021/acschemneuro.3c00267 · PMID 37474114
- Journal / agency Gallardo-Godoy A, Fierro A, McLean TH, Castillo M, Cassels BK, Reyes-Parada M, Nichols DE. Sulfur-substituted alpha-alkyl phenethylamines as selective and reversible MAO-A inhibitors: biological activities, CoMFA analysis, and active site modeling. Journal of Medicinal Chemistry. April 2005. doi:10.1021/jm0493109 · PMID 15801832
Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), TripSit factsheets, PubChem (public domain). Each value links to the exact revision it came from.