PARGY-LAD
Dosage
Oral bands as drawn from PsychonautWiki's ranges below. The table is the source of truth.
Oral
| Source | Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|---|
| PsychonautWiki | 50 µg PW | 125–275 µg PW | 275–500 µg PW | 500–700 µg PW | 700 µg+ PW |
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Duration
Mixing
Acute combinations: what happens when these are taken close together. Entries backed by a medical journal or agency are listed first.
Backed by medical journals
PsychonautWiki also lists dangerous combinations shared across a whole group (psychedelics) in a table this page does not copy. Read that list on PsychonautWiki.
Risks and toxicity
The toxicity and long-term health effects of recreational PARGY-LAD do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because PARGY-LAD is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried PARGY-LAD suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption. PW
It is strongly recommended that one use harm reduction practices when using this substance. PW
Tolerance and addiction potential
While no formal studies have been conducted, PARGY-LAD is likely not habit-forming and it is reasonable to speculate that the desire to use it can actually decrease with repeated administration. As with most psychedelics, it likely possesses what is considered an intrinsic, self-regulating aspect to it. PW
Tolerance to the effects of PARGY-LAD is built almost immediately after ingestion. After that, it takes about 5-7 days for the tolerance to be reduced to half and 14 days to be back at baseline (in the absence of further consumption). PARGY-LAD presents cross-tolerance with all psychedelics, meaning that after the consumption of PARGY-LAD all psychedelics will have a reduced effect. PW
Testing
Effects
Overview
6-Propynyl-6-nor- Lysergic acid diethylamide (also known as N-Propynylnorlysergic acid N,N-diethylamide, N-PropynylnorLSD or simply PARGY-LAD) is a novel synthetic psychedelic substance of the lysergamide chemical class that produces a similar albeit significantly less distinct array of LSD-like psychedelic effects when administered. It is a close structural homolog of LSD known mainly for its obscurity and lack of distinguishing features. PW
PARGY-LAD, also known as 6-propynyl-6-nor-LSD or 6-propargyl-6-nor-LSD, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD).[1] WP
History
History
PARGY-LAD was developed by David E. Nichols and colleagues at Purdue University in the 1980s and is described by Alexander Shulgin in his 1997 book TiHKAL (Tryptamines I Have Known and Loved).[1]
Legal status
- Germany: PARGY-LAD is controlled under the NpSG (New Psychoactive Substances Act) as of July 18, 2019. Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.[3]
[4] [5] PW - Latvia: PARGY-LAD is illegal in Latvia. Although it isn't officially scheduled, it is controlled as an LSD structural analog due to an amendment made on June 1, 2015.[6] PW
- Switzerland: PARGY-LAD is not specifically named under Buchstabe A, B, C and D. It is also not controlled as a defined derivative of Lysergic Acid under Verzeichnis E point 263 due to its alkynyl substitution which is not included. It can be considered legal. PW
- United Kingdom: As of January 7, 2015, PARGY-LAD is specifically named in the U.K. Misuse of Drugs Act as a Class A drug.[7] PW
Pharmacology
Chemistry
- Formula
- C22H25N3O PC
- Molar mass (g/mol)
- 347.5 PC
- IUPAC name (computed by PubChem)
- (6aR,
9R) PC- N, N- diethyl- 7- prop- 2- ynyl- 6, 6a, 8, 9- tetrahydro- 4H- indolo[4, 3- fg] quinoline- 9- carboxamide - SMILES
- CCN(CC)
C(=O) PC[C@H] 1CN([C@@H] 2CC3=CNC4=CC=CC(=C34) C2=C1) CC#C - InChIKey
- BPJKJUFQSNRQCR-
OXQOHEQNSA- PCN - PubChem CID
- 139030999
User reports
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References
- Other Nichols DE, Oberlender R, McKenna DJ. Biochemistry and Physiology of Substance Abuse. 1991
- Harm reduction site 51. PRO-LAD
- Other Anlage NpSG
- Other Verordnung zur Änderung der Anlage des Neue-psychoaktive-Stoffe-Gesetzes und von Anlagen des Betäubungsmittelgesetzes
- Other § 4 NpSG
- Other Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem
- Other Advisory Council on the Misuse of Drugs (ACMD). Update of the generic definition for tryptamines. June 10, 2014
Text and values on this page are quoted from PsychonautWiki (CC BY-SA 4.0), Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.