Proscaline
Dosage
Oral bands as drawn from PsychonautWiki's ranges below. The table is the source of truth.
When sources disagree, both rows are shown as published. Nothing is averaged or merged.
Oral
| Source | Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|---|
| PsychonautWiki | 10 mg PW | 15–30 mg PW | 30–40 mg PW | 40–60 mg PW | 60 mg+ PW |
| TripSit | 15 mg TS | 15–30 mg TS | 30–40 mg TS | 40–60 mg TS | – |
TripSit dose text
TripSit's factsheet also states its doses as text.
Oral Threshold: 15mg's Light: 15-30mg's Common: 30-40mg's Strong: 40-60mg's TS
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Duration
| Route · source | Onset | Come-up | Peak | Offset | Total | After-effects |
|---|---|---|---|---|---|---|
| Oral · PsychonautWiki | 30–60 minutes PW | – | – | – | 8–12 hours PW | 3–5 hours PW |
TripSit factsheet
Mixing
Acute combinations: what happens when these are taken close together. Entries backed by a medical journal or agency are listed first.
Backed by medical journals
Risks and toxicity
The toxicity and long-term health effects of recreational proscaline use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. Anecdotal evidence from people who have tried proscaline within the psychedelic community suggests that there are no negative health effects attributed to trying this drug, but nothing can be completely guaranteed. PW
It is strongly recommended that one use harm reduction practices when using this drug. PW
Tolerance and addiction potential
Proscaline is not habit-forming, and the desire to use it can actually decrease with use. It is most often self-regulating. PW
Tolerance to the effects of proscaline is built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). proscaline presents cross-tolerance with all psychedelics, meaning that after the consumption of proscaline all psychedelics will have a reduced effect. PW
Testing
Effects
Euphoriaempathyinsightbrightened colourClosed/Open eye visualsenhanced tactile sensationmental/physical stimulationdecreased appetitepupil dilationrestlessnesschange in perceptionego softeningsweating/chillsmuscle tensionconfusioninsomnia TS
Shulgin notes
These figures come from the Shulgins' own small trials, published decades ago. They are history, not a dosing guide: they were never checked the way a harm reduction dose table is, and batches, purity and people differ.
Read entry #140 in Erowid's online library
From PiHKAL and TiHKAL by Alexander and Ann Shulgin, as tabulated in Wikipedia's articles on the books (CC BY-SA 4.0). The books' text belongs to the Shulgins, so only the listed figures and a link are given here. Synthesis details are never shown on this site.
Overview
4-Propyloxy-3,5-dimethoxyphenethylamine (also known as proscaline) is a lesser-known psychedelic substance of the phenethylamine class. It is a structurally related to mescaline and belongs to a series of mescaline analogs that include isoproscaline, escaline and allylescaline.[1] PW
A very uncommon psychedelic stimulant and phenethylamine and analogue on mescaline with similar effects. Roughly 5-7 times more potent than mescaline by weight. TS
Proscaline, also known as 4-propoxy-3,5-dimethoxyphenethylamine, is a psychedelic drug of the phenethylamine and scaline families related to mescaline. It is taken orally.[2]
History
History
Proscaline was first synthesized and studied by Otakar Leminger in 1972. The drug was later synthesized by Alexander Shulgin and further described in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved). It was encountered as a novel designer drug in Europe in 2013.[2]
Legal status
- Germany: Proscaline is controlled under the NpSG (New Psychoactive Substances Act) as of November 26, 2016. Production and import with the aim to place it on the market, administration to another person, placing it on the market and trading is punishable. Possession is illegal but not punishable. The legislator considers it possible that orders of proscaline are punishable as an incitement to place it on the market.[8–12] PW
- Switzerland: Proscaline can be considered a controlled substance as a defined derivative of Phenethylamine under Verzeichnis E point 130. It is legal when used for scientific or industrial use.[13] PW
- United Kingdom: Proscaline is a Class A controlled substance as it is covered by the phenethylamine derivatives clause of the Misuse of Drugs Act of 1971. PW⚠ PsychonautWiki itself has flagged this text: citation needed.
- United States: Proscaline is uncontrolled in the United States. PW
Canada
Proscaline is not a controlled substance in Canada as of 2025.[14] WP
United kingdom
Proscaline is a Class A controlled substance in the United Kingdom. WP⚠ Wikipedia itself has flagged this text: citation needed.
United states
Proscaline is not an explicitly controlled substance in the United States. However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.[15] WP
Pharmacology
Pharmacodynamics
Proscaline is a serotonin 5-HT₂ receptor agonist, including of the serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptors. Activation of the serotonin 5-HT2A receptor is thought to be responsible for its psychedelic effects. The drug is much more potent as an agonist of the serotonin 5-HT2C receptor than as an agonist of the serotonin 5-HT2A or 5-HT2B receptors.[16]
It produces the head-twitch response, a behavioral proxy of psychedelic effects, in rodents.[3]
Chemistry
User reports
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References
- Other Alexander Shulgin; Ann Shulgin. PiHKAL: A Chemical Love Story. 1991
- Harm reduction site Erowid Online Books: "PIHKAL" - #140 P
- Journal / agency Halberstadt AL, Chatha M, Klein AK, Wallach J, Brandt SD. Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species. Neuropharmacology. May 2020. doi:10.1016/j.neuropharm.2019.107933 · PMID 31917152 · PMC9191653
- Journal / agency Otakar Leminger. Příspěvek k chemii v jádře alkoxylovaných β-fenoetylaminů – II: O některých v jádře alkoxylovaných β-fenoetylaminech, resp. jejich sulfátech. Chemický Průmysl. 1972
- Journal / agency King LA. New phenethylamines in Europe. Drug Test Anal. 2014. doi:10.1002/dta.1570 · PMID 24574327
- Harm reduction site EMCDDA–Europol 2013 Annual Report on the implementation of Council Decision 2005/387/JHA
- Journal / agency Halberstadt AL, Chatha M, Chapman SJ, Brandt SD. Comparison of the behavioral effects of mescaline analogs using the head twitch response in mice. J Psychopharmacol. March 2019. doi:10.1177/0269881119826610 · PMID 30789291 · PMC6848748
- Other Anlage NpSG
- Other Gesetz zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe. November 21, 2016
- Other § 4 NpSG
- Other § 3 NpSG
- Other Gesetzentwurf der Bundesregierung: Entwurf eines Gesetzes zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe. May 30, 2016
- Other Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien
- Other Controlled Drugs and Substances Act
- Other Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026). January 2026
- Journal / agency Wallach J, Cao AB, Calkins MM, Heim AJ, Lanham JK, Bonniwell EM, Hennessey JJ, Bock HA, Anderson EI, Sherwood AM, Morris H, de Klein R, Klein AK, Cuccurazzu B, Gamrat J, Fannana T, Zauhar R, Halberstadt AL, McCorvy JD. Identification of 5-HT2A receptor signaling pathways associated with psychedelic potential. Nat Commun. December 2023. doi:10.1038/s41467-023-44016-1 · PMID 38102107 · PMC10724237
- Other McCorvy JD. Mapping the binding site of the 5-HT2A receptor using mutagenesis and ligand libraries: Insights into the molecular actions of psychedelics. 16 January 2013
Text and values on this page are quoted from PsychonautWiki (CC BY-SA 4.0), Wikipedia (CC BY-SA 4.0), TripSit factsheets, PubChem (public domain). Each value links to the exact revision it came from.