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Serotonergic psychedelic · Hallucinogen

2CT-5-EtO

Original Wikipedia articleen.wikipedia.org/wiki/2CT-5-EtO revision used (24 October 2026)

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Overview

2CT-5-EtO, also known as 2-methoxy-4-methylthio-5-ethoxyphenethylamine, is a psychedelic drug of the phenethylamine, 2C, and TWEETIO families related to 2C-T. It is the derivative of 2C-T in which the methoxy group at the 5 position has been replaced with an ethoxy group.[1][2][3] WP

According to Alexander Shulgin in his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, 2CT-5-EtO's dose is 30 mg orally and its duration is perhaps 15 hours. The effects of 2CT-5-EtO have been reported to include body awareness and modest closed-eye visuals, with the experience being described as quiet, peaceful, contemplative, and insightful. Other effects included insomnia and lots of dreams during sleep.[1][2][3] WP

The chemical synthesis of 2CT-5-EtO has been described.[1] WP

2CT-5-EtO was first described in the literature by Shulgin in PiHKAL in 1991. It was developed and tested by Darrell Lemaire, with publication via personal communication with Shulgin. The drug is a controlled substance in Canada under phenethylamine blanket-ban language.[1][2][4–8] WP

Drug class

Serotonergic psychedelic Hallucinogen WP

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Chemistry

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Harm reduction information

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Sources

  1. Other The 5-EtO-homologue of 2C-T is 5-ethoxy-2-methoxy-4-methylthiophenethylamine, or 2CT-5ETO. The benzaldehyde (5-ethoxy-2-methoxy-4-(methylthio)benzaldehyde) was impure, and had a melting point of about 66 °C, the nitrostyrene intermediate a melting point of 133–134 °C, and the final hydrochloride a melting point of 184–185 °C. There was a body awareness and modest eyes-closed visuals following the use of 30 milligrams of 2CT-5ETO. The experience was quiet, peaceful, contemplative, and insightful. The duration was perhaps 15 hours and Halcion was needed to allow sleep. There were a lot of dreams, and the next day was restful CitePiHKAL
  2. Other Shulgin AT. Hallucinogens: A Forensic Drug Handbook. 2003
  3. Other Trachsel D, Lehmann D, Enzensperger C. Phenethylamine: von der Struktur zur Funktion. 2013
  4. Harm reduction site Erowid Darrell Lemaire Vault
  5. Other The Lazy Lizard School of Hedonism. 7 December 2016
  6. Other Nez H, Lemaire D. Radiant Minds: Scientists Explore the Dimensions of Consciousness. 2010
  7. Harm reduction site Nez H, Lemaire D (Lazar). Certain Exotic Transmitters as Smart Pills or Compounds that Increase the Capacity for Mental Work in Humans: A Story About LAZAR as Told by Hosteen Nez. 1990
  8. Other Controlled Drugs and Substances Act

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