Stimulant · Psychedelic

2,5-DMA

Also called DOH, 2,5-Dimethoxyamphetamine

Original Wikipedia articleen.wikipedia.org/wiki/Dimethoxyamphetamine revision used (24 October 2026)

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Common dose · Oral40–80 mg PW

Total6–8 hours PW

Dosage

Light

Common

Strong

Heavy

104080200mg

Oral bands as drawn from PsychonautWiki's ranges below. The table is the source of truth.

Oral

Source	Threshold	Light	Common	Strong	Heavy
PsychonautWiki	10 mg PW	10–40 mg PW	40–80 mg PW	80–200 mg PW	200 mg+ PW

What dose are you on? (self-reported, unverified)

Read this first. These numbers come from anonymous visitors typing in a box. Nobody checks them. People misjudge, mistype, troll, or take untested products of unknown strength. They are not a dose guide and never override the sourced table above. They exist only so the sourced ranges can be compared with what people say they take. If you are deciding what to take, use the sourced table, start low, and read the risks section.

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Duration

Route · source	Onset	Come-up	Peak	Offset	Total	After-effects
Oral · PsychonautWiki	–	–	–	–	6–8 hours PW	–

Mixing

For best safety practice, don't mix this drug with other stimulants.

Why: vasoconstriction, heart rate and blood pressure. PsychonautWiki says:

“... may be dangerous to combine with other stimulants ... as they can increase one's heart rate and blood pressure to dangerous levels.” (PsychonautWiki, dangerous interactions table, "Stimulants" row, revision 148925)
“Vasoconstriction can be described as a narrowing of the veins and blood vessels which results from a contraction of their muscular wall.” (PsychonautWiki, Vasoconstriction, revision 170337)
“... it can also occur under the influence of traditional stimulants such as methamphetamine, caffeine, and MDMA.” (PsychonautWiki, Vasoconstriction, revision 170337)
“Increased blood pressure is most commonly induced under the influence of heavy dosages of vasoconstricting compounds, such as traditional stimulants and stimulating psychedelics.” (PsychonautWiki, Increased blood pressure, revision 152273)

Quotes from PsychonautWiki, CC BY-SA 4.0.

Acute combinations: what happens when these are taken close together. Entries backed by a medical journal or agency are listed first.

Backed by medical journals

Awaiting sourcePeer-reviewed reports on acute combinations, from PubMed and the journals the harm reduction sites cite.

PsychonautWiki also lists dangerous combinations shared across a whole group (psychedelics) in a table this page does not copy. Read that list on PsychonautWiki.

Risks and toxicity

The toxicity and long-term health effects of recreational 2,5-DMA use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 2,5-DMA is a research chemical with very little history of human usage. PW

Anecdotal reports from those who have tried 2,5-DMA suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption. PW

It is strongly recommended that one use harm reduction practices, such as volumetric dosing, when using this substance so as to ensure the accurate administration of the intended dose. PW

Tolerance and addiction potential

Although no formal studies have been conducted, it is not unreasonable to assume that as is the case with psychedelics in general, 2,5-DMA is not habit-forming and that the desire to use it can actually decrease with use. However, it's stimulating properties do provide a possible risk of addiction which would be associated with other stimulants. PW

Tolerance to the effects of 2,5-DMA is built after ingestion over the couse of multiple days. After that, it takes about 3-5 days for the tolerance to be reduced to half and 7-10 days to be back at baseline (in the absence of further consumption). 2,5-DMA may present cross-tolerance, although unlikely, with all psychedelics, meaning that after the consumption of 2,5-DMA all psychedelics will have a reduced effect. It may also produce tolerance to stimulants as well. PW

Testing

Awaiting sourceReagent reactions and test kit guidance from a harm reduction testing service.

Effects

Awaiting sourceSubjective and physical effects from PsychonautWiki or TripSit.

Shulgin notes

These figures come from the Shulgins' own small trials, published decades ago. They are history, not a dosing guide: they were never checked the way a harm reduction dose table is, and batches, purity and people differ.

Book: PiHKAL (1991), entry #54
Dose listed: 80–160 mg orally WP
Duration listed: 6–8 hours WP

Read entry #54 in Erowid's online library

From PiHKAL and TiHKAL by Alexander and Ann Shulgin, as tabulated in Wikipedia's articles on the books (CC BY-SA 4.0). The books' text belongs to the Shulgins, so only the listed figures and a link are given here. Synthesis details are never shown on this site.

Overview

2,5-Dimethoxyamphetamine (also known as 2,5-DMA, unformally as simply DMA, and unofficially as DOH) is a lesser-known psychoactive substance of the amphetamine class. 2,5-DMA belongs to the DOx family of substituted amphetamines. PW

History

Awaiting sourceHistory and culture from Wikipedia or PsychonautWiki, with their citations.

Legal status

Germany: 2,5-DMA is controlled under the NpSG (New Psychoactive Substances Act) as of November 26, 2016. Production and import with the aim to place it on the market, administration to another person, placing it on the market and trading is punishable. Possession is illegal but not punishable. The legislator considers it possible that orders of 2C-H are punishable as an incitement to place it on the market.[1–4] PW⚠ PsychonautWiki itself has flagged this text: citation needed.
Switzerland: 2,5-DMA can be considered a controlled substance as a defined derivative of Phenethylamine under Verzeichnis E point 130. It is legal when used for scientific or industrial use.[5] PW
United Kingdom: 2,5-DMA is a Class A drug in the United Kingdom as a result of the phenethylamine catch-all clause.[6] PW
United States: 2,5-DMA could be considered an analog of 2C-H or amphetamine, which could make it illegal under the Federal Analog Act. PW⚠ PsychonautWiki itself has flagged this text: citation needed.

Pharmacology

Awaiting sourcePharmacology from Wikipedia and the journal papers it cites.

Chemistry

Awaiting sourceFormula, structure and identifiers from PubChem.

User reports

Erowid erowid.org

Listings

Awaiting sourceExperience Vault listing and report categories.

Bluelight bluelight.org

Listings

Awaiting sourceTrip report threads and this substance's discussion forum.

Reddit reddit.com

Listings

Awaiting sourceTrip report posts and the relevant subreddits.

Pop culture

No references added yet.

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References

Other Gesetz zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe. November 21, 2016
Other § 4 NpSG
Other § 3 NpSG
Other Gesetzentwurf der Bundesregierung: Entwurf eines Gesetzes zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe. May 30, 2016
Other Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien
Other Schedule 2: Part I: Class A Drugs

Text and values on this page are quoted from PsychonautWiki (CC BY-SA 4.0), Wikipedia (CC BY-SA 4.0). Each value links to the exact revision it came from.